Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesis

Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesis

Abstract: Deficiencies in coagulation factor VIII (FVIII, F8) result in the bleeding disorder hemophilia A. An emerging novel therapeutic strategy for bleeding disorders is to enhance hemostasis by limiting natural anticoagulants, such as antithrombin (AT3). To study pro/anticoagulant hemostatic bal...

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Bibliographic Details
Main Authors: Azhwar Raghunath, Catherine E. Richter, Megan S. Griffin, Sylvia M. Emly, Murat Yaman, Valder R. Arruda, Benjamin J. Samelson-Jones, Jordan A. Shavit
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925001600
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