Weekly Intraperitoneal Injection of Tamoxifen in an Inducible In Vivo Model of Junctional Epidermolysis Bullosa Generates Early and Advanced Disease Phenotypes

Weekly Intraperitoneal Injection of Tamoxifen in an Inducible In Vivo Model of Junctional Epidermolysis Bullosa Generates Early and Advanced Disease Phenotypes

Junctional epidermolysis bullosa caused by loss-of-function variants in genes encoding the skin basement membrane proteins laminin 332, type XVII collagen, or integrin α6β4 affects patients from birth with severe blistering, eventually leading to scarring and early lethality. In this study, we have...

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Bibliographic Details
Main Authors: Eleri Mai Jones, Priya Garcha, Monique Aumailley, Edel Anne O’Toole, Emanuel Rognoni, Matthew Caley
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:JID Innovations
Subjects:
Inducible transgenic model
Junctional EB
Laminin
Skin inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2667026724000791
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