Redox Metabolism and Autonomic Regulation During Aging: Can Heart Rate Variability Be Used to Monitor Healthy Longevity?
The functionality of redox metabolism is frequently named as an important contributor to the processes of aging and anti-aging. Excessive activation of free radical reactions accompanied by the inability of the antioxidant defense (AOD) mechanisms to control the flow of the reactive oxygen species (...
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/161 |
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| author | Olha Yelisyeyeva Danylo Kaminskyy Marta Semen Ilona Chelpanova Khrystyna O. Semen |
| author_facet | Olha Yelisyeyeva Danylo Kaminskyy Marta Semen Ilona Chelpanova Khrystyna O. Semen |
| author_sort | Olha Yelisyeyeva |
| collection | DOAJ |
| description | The functionality of redox metabolism is frequently named as an important contributor to the processes of aging and anti-aging. Excessive activation of free radical reactions accompanied by the inability of the antioxidant defense (AOD) mechanisms to control the flow of the reactive oxygen species (ROS) leads to the persistence of oxidative stress, hypoxia, impaired mitochondrial energy function and reduced ATP potential. From a long-term perspective, such changes contribute to the development of chronic diseases and facilitate aging. In turn, preconditioning of a biosystem with small doses of stressful stimuli might cause mobilization of the mechanisms of AOD and control an excessive flow of ROS, which supports optimal functioning of the redox reactions. Those mechanisms are of crucial importance for anti-aging and are also known as a eustress or hormetic response. To ensure continuous support of mild pro-oxidant activity in a metabolic system, close monitoring and timely corrections preventing the development of excessive ROS production are required. The paper introduces the potential of heart rate variability (HRV) as a biomarker of functional and metabolic reserves and a tool to measure stress resilience during aging. The practical approaches to interpretation of HRV are provided based on total power, changes in total power in response to an orthostatic test and activities of all spectral components. It is suggested that the complex of those parameters can reflect the depth of oxidative stress and may be used to guide lifestyle interventions and promote active longevity. |
| format | Article |
| id | doaj-art-f8b1814c79eb4cbb966317964e94f0ce |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-f8b1814c79eb4cbb966317964e94f0ce2025-01-24T13:24:14ZengMDPI AGBiomedicines2227-90592025-01-0113116110.3390/biomedicines13010161Redox Metabolism and Autonomic Regulation During Aging: Can Heart Rate Variability Be Used to Monitor Healthy Longevity?Olha Yelisyeyeva0Danylo Kaminskyy1Marta Semen2Ilona Chelpanova3Khrystyna O. Semen4Department of Histology, Cytology and Embryology, Danylo Halytsky Lviv National Medical University, 79010 Lviv, UkraineDepartment of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 79010 Lviv, UkraineDepartment of Propaedeutics of Pediatrics and Medical Genetics, Danylo Halytsky Lviv National Medical University, 79010 Lviv, UkraineDepartment of Histology, Cytology and Embryology, Danylo Halytsky Lviv National Medical University, 79010 Lviv, UkraineCampus Venlo, Maastricht University, 5911 BV Venlo, The NetherlandsThe functionality of redox metabolism is frequently named as an important contributor to the processes of aging and anti-aging. Excessive activation of free radical reactions accompanied by the inability of the antioxidant defense (AOD) mechanisms to control the flow of the reactive oxygen species (ROS) leads to the persistence of oxidative stress, hypoxia, impaired mitochondrial energy function and reduced ATP potential. From a long-term perspective, such changes contribute to the development of chronic diseases and facilitate aging. In turn, preconditioning of a biosystem with small doses of stressful stimuli might cause mobilization of the mechanisms of AOD and control an excessive flow of ROS, which supports optimal functioning of the redox reactions. Those mechanisms are of crucial importance for anti-aging and are also known as a eustress or hormetic response. To ensure continuous support of mild pro-oxidant activity in a metabolic system, close monitoring and timely corrections preventing the development of excessive ROS production are required. The paper introduces the potential of heart rate variability (HRV) as a biomarker of functional and metabolic reserves and a tool to measure stress resilience during aging. The practical approaches to interpretation of HRV are provided based on total power, changes in total power in response to an orthostatic test and activities of all spectral components. It is suggested that the complex of those parameters can reflect the depth of oxidative stress and may be used to guide lifestyle interventions and promote active longevity.https://www.mdpi.com/2227-9059/13/1/161aginganti-agingheart rate variabilityhormetic response |
| spellingShingle | Olha Yelisyeyeva Danylo Kaminskyy Marta Semen Ilona Chelpanova Khrystyna O. Semen Redox Metabolism and Autonomic Regulation During Aging: Can Heart Rate Variability Be Used to Monitor Healthy Longevity? Biomedicines aging anti-aging heart rate variability hormetic response |
| title | Redox Metabolism and Autonomic Regulation During Aging: Can Heart Rate Variability Be Used to Monitor Healthy Longevity? |
| title_full | Redox Metabolism and Autonomic Regulation During Aging: Can Heart Rate Variability Be Used to Monitor Healthy Longevity? |
| title_fullStr | Redox Metabolism and Autonomic Regulation During Aging: Can Heart Rate Variability Be Used to Monitor Healthy Longevity? |
| title_full_unstemmed | Redox Metabolism and Autonomic Regulation During Aging: Can Heart Rate Variability Be Used to Monitor Healthy Longevity? |
| title_short | Redox Metabolism and Autonomic Regulation During Aging: Can Heart Rate Variability Be Used to Monitor Healthy Longevity? |
| title_sort | redox metabolism and autonomic regulation during aging can heart rate variability be used to monitor healthy longevity |
| topic | aging anti-aging heart rate variability hormetic response |
| url | https://www.mdpi.com/2227-9059/13/1/161 |
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