A stress-dependent TDP-43 SUMOylation program preserves neuronal function

A stress-dependent TDP-43 SUMOylation program preserves neuronal function

Abstract Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are overwhelmingly linked to TDP-43 dysfunction. Mutations in TDP-43 are rare, indicating that the progressive accumulation of exogenous factors – such as cellular stressors – converge on TDP-43 to play a key role in dise...

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Bibliographic Details
Main Authors: Terry R. Suk, Caroline E. Part, Jenny L. Zhang, Trina T. Nguyen, Meghan M. Heer, Alejandro Caballero-Gómez, Veronica S. Grybas, Paul M. McKeever, Benjamin Nguyen, Tahir Ali, Steve M. Callaghan, John M. Woulfe, Janice Robertson, Maxime W. C. Rousseaux
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Neurodegeneration
Subjects:
ALS
FTD
TDP-43
SUMOylation
Pathology
Mouse Model
Online Access:https://doi.org/10.1186/s13024-025-00826-z
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