Metabolic and Clinical Consequences of Hyperthyroidism on Bone Density
In 1891, Von Recklinghausen first established the association between the development of osteoporosis in the presence of overt hyperthyroidism. Subsequent reports have demonstrated that BMD loss is common in frank hyperthyroidism, and, to a lesser extent, in subclinical presentations. With the intro...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/638727 |
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| author | Jagoda Gorka Regina M. Taylor-Gjevre Terra Arnason |
| author_facet | Jagoda Gorka Regina M. Taylor-Gjevre Terra Arnason |
| author_sort | Jagoda Gorka |
| collection | DOAJ |
| description | In 1891, Von Recklinghausen first established the association between the development of osteoporosis in the presence of overt hyperthyroidism. Subsequent reports have demonstrated that BMD loss is common in frank hyperthyroidism, and, to a lesser extent, in subclinical presentations. With the introduction of antithyroid medication in the 1940s to control biochemical hyperthyroidism, the accompanying bone disease became less clinically apparent as hyperthyroidism was more successfully treated medically. Consequently, the impact of the above normal thyroid hormones in the pathogenesis of osteoporosis may be presently underrecognized due to the widespread effective treatments.
This review aims to present the current knowledge of the consequences of hyperthyroidism on bone metabolism. The vast number of recent papers touching on this topic highlights the recognized impact of this common medical condition on bone health. Our focus in this review was to search for answers to the following questions. What is the mechanisms of action of thyroid hormones on bone metabolism? What are the clinical consequences of hyperthyroidism on BMD and fracture risk? What differences are there between men and women with thyroid disease and how does menopause change the clinical outcomes? Lastly, we report how different treatments for hyperthyroidism benefit thyroid hormone-induced osteoporosis. |
| format | Article |
| id | doaj-art-f8a1d7d4f58c46aa8dfa8c5a99e04f26 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f8a1d7d4f58c46aa8dfa8c5a99e04f262025-02-03T01:22:48ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/638727638727Metabolic and Clinical Consequences of Hyperthyroidism on Bone DensityJagoda Gorka0Regina M. Taylor-Gjevre1Terra Arnason2Department of Medicine, University of Saskatchewan, Saskatoon, S7N 0W8, CanadaDivision of Rheumatology, Department of Medicine, University of Saskatchewan, Saskatoon, S7N 0W8, CanadaDivision of Endocrinology and Metabolism, Department of Medicine, University of Saskatchewan, Saskatoon, S7N 0W8, CanadaIn 1891, Von Recklinghausen first established the association between the development of osteoporosis in the presence of overt hyperthyroidism. Subsequent reports have demonstrated that BMD loss is common in frank hyperthyroidism, and, to a lesser extent, in subclinical presentations. With the introduction of antithyroid medication in the 1940s to control biochemical hyperthyroidism, the accompanying bone disease became less clinically apparent as hyperthyroidism was more successfully treated medically. Consequently, the impact of the above normal thyroid hormones in the pathogenesis of osteoporosis may be presently underrecognized due to the widespread effective treatments. This review aims to present the current knowledge of the consequences of hyperthyroidism on bone metabolism. The vast number of recent papers touching on this topic highlights the recognized impact of this common medical condition on bone health. Our focus in this review was to search for answers to the following questions. What is the mechanisms of action of thyroid hormones on bone metabolism? What are the clinical consequences of hyperthyroidism on BMD and fracture risk? What differences are there between men and women with thyroid disease and how does menopause change the clinical outcomes? Lastly, we report how different treatments for hyperthyroidism benefit thyroid hormone-induced osteoporosis.http://dx.doi.org/10.1155/2013/638727 |
| spellingShingle | Jagoda Gorka Regina M. Taylor-Gjevre Terra Arnason Metabolic and Clinical Consequences of Hyperthyroidism on Bone Density International Journal of Endocrinology |
| title | Metabolic and Clinical Consequences of Hyperthyroidism on Bone Density |
| title_full | Metabolic and Clinical Consequences of Hyperthyroidism on Bone Density |
| title_fullStr | Metabolic and Clinical Consequences of Hyperthyroidism on Bone Density |
| title_full_unstemmed | Metabolic and Clinical Consequences of Hyperthyroidism on Bone Density |
| title_short | Metabolic and Clinical Consequences of Hyperthyroidism on Bone Density |
| title_sort | metabolic and clinical consequences of hyperthyroidism on bone density |
| url | http://dx.doi.org/10.1155/2013/638727 |
| work_keys_str_mv | AT jagodagorka metabolicandclinicalconsequencesofhyperthyroidismonbonedensity AT reginamtaylorgjevre metabolicandclinicalconsequencesofhyperthyroidismonbonedensity AT terraarnason metabolicandclinicalconsequencesofhyperthyroidismonbonedensity |