Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation: A Proposal from a Case
Bronchiolitis obliterans (BO) is one of the serious, noninfectious pulmonary complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Early diagnosis of BO is usually difficult because patients are often asymptomatic at an initial stage of the disease and pathologic findin...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/957612 |
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| author | Rie Nakamoto-Matsubara Hidekazu Nishikii Kenji Yamada Masafumi Ito Yuichi Hasegawa Naoki Kurita Naoshi Obara Yasushi Okoshi Kazumi Suzukawa Yasuhisa Yokoyama Mamiko Sakata-Yanagimoto Masayuki Noguchi Shigeru Chiba |
| author_facet | Rie Nakamoto-Matsubara Hidekazu Nishikii Kenji Yamada Masafumi Ito Yuichi Hasegawa Naoki Kurita Naoshi Obara Yasushi Okoshi Kazumi Suzukawa Yasuhisa Yokoyama Mamiko Sakata-Yanagimoto Masayuki Noguchi Shigeru Chiba |
| author_sort | Rie Nakamoto-Matsubara |
| collection | DOAJ |
| description | Bronchiolitis obliterans (BO) is one of the serious, noninfectious pulmonary complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Early diagnosis of BO is usually difficult because patients are often asymptomatic at an initial stage of the disease and pathologic findings are available mostly at the late stages. Therefore, the diagnosis of the disease is based on the pulmonary function test using the National Institute of Health consensus criteria.
Here, we report a case of slowly progressive BO. A biopsy specimen at an early stage demonstrated alveolar destruction with lymphocyte infiltration in bronchial walls and mild narrowing of bronchioles without fibrosis, those were strongly indicative of initial pathologic changes of BO. Definitive BO followed, which was proven by both clinical course and autopsy. While alloreactive lymphocytes associated with chronic graft-versus-host disease are believed to initiate BO, we present a rare case that directly implies such a scenario. |
| format | Article |
| id | doaj-art-f8915fa46c734ea3894765327d3928ec |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-f8915fa46c734ea3894765327d3928ec2025-02-03T01:26:31ZengWileyCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/957612957612Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation: A Proposal from a CaseRie Nakamoto-Matsubara0Hidekazu Nishikii1Kenji Yamada2Masafumi Ito3Yuichi Hasegawa4Naoki Kurita5Naoshi Obara6Yasushi Okoshi7Kazumi Suzukawa8Yasuhisa Yokoyama9Mamiko Sakata-Yanagimoto10Masayuki Noguchi11Shigeru Chiba12Department of Hematology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanDepartment of Hematology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanDepartment of Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanDepartment of Pathology, Japanese Red Cross Nagoya Daiichi Hospital, 3-35 Michishita-cho, Nakamura, Nagoya 453-8511, JapanDepartment of Hematology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanDepartment of Hematology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanDepartment of Hematology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanDepartment of Hematology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanDepartment of Hematology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanDepartment of Hematology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanDepartment of Hematology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanDepartment of Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanDepartment of Hematology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenoudai Tsukuba, Ibaraki 305-8575, JapanBronchiolitis obliterans (BO) is one of the serious, noninfectious pulmonary complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Early diagnosis of BO is usually difficult because patients are often asymptomatic at an initial stage of the disease and pathologic findings are available mostly at the late stages. Therefore, the diagnosis of the disease is based on the pulmonary function test using the National Institute of Health consensus criteria. Here, we report a case of slowly progressive BO. A biopsy specimen at an early stage demonstrated alveolar destruction with lymphocyte infiltration in bronchial walls and mild narrowing of bronchioles without fibrosis, those were strongly indicative of initial pathologic changes of BO. Definitive BO followed, which was proven by both clinical course and autopsy. While alloreactive lymphocytes associated with chronic graft-versus-host disease are believed to initiate BO, we present a rare case that directly implies such a scenario.http://dx.doi.org/10.1155/2012/957612 |
| spellingShingle | Rie Nakamoto-Matsubara Hidekazu Nishikii Kenji Yamada Masafumi Ito Yuichi Hasegawa Naoki Kurita Naoshi Obara Yasushi Okoshi Kazumi Suzukawa Yasuhisa Yokoyama Mamiko Sakata-Yanagimoto Masayuki Noguchi Shigeru Chiba Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation: A Proposal from a Case Case Reports in Hematology |
| title | Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation: A Proposal from a Case |
| title_full | Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation: A Proposal from a Case |
| title_fullStr | Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation: A Proposal from a Case |
| title_full_unstemmed | Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation: A Proposal from a Case |
| title_short | Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation: A Proposal from a Case |
| title_sort | early pathologic findings of bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation a proposal from a case |
| url | http://dx.doi.org/10.1155/2012/957612 |
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