The difference between MelP5 and melittin membrane poration

Abstract Melittin, a natural peptide found in bees, has been shown to induce pore formation in cell membranes. However, its artificial mutant, MelP5 can do so at concentrations 200 times lower than melittin. The mechanism of the enhanced portion ability is not fully understood. By conducting all-ato...

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Bibliographic Details
Main Authors: Bing Zan, Martin B. Ulmschneider, Jakob P. Ulmschneider
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-91951-8
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