Mitral and tricuspid stenosis caused by light chain cardiac amyloid deposition
Abstract Cardiac amyloidosis results in an infiltrative restrictive cardiomyopathy, with a number of characteristic features: biventricular hypertrophy, abnormal myocardial global longitudinal strain with relative apical sparing, biatrial dilation, and small pericardial effusion along with conductio...
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| Format: | Article |
| Language: | English |
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Wiley
2020-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.12668 |
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| author | Varinder K. Randhawa Sneha Vakamudi Dermot M. Phelan Christy J. Samaras Jesse K. McKenney Mazen Hanna Antonio L. Perez |
| author_facet | Varinder K. Randhawa Sneha Vakamudi Dermot M. Phelan Christy J. Samaras Jesse K. McKenney Mazen Hanna Antonio L. Perez |
| author_sort | Varinder K. Randhawa |
| collection | DOAJ |
| description | Abstract Cardiac amyloidosis results in an infiltrative restrictive cardiomyopathy, with a number of characteristic features: biventricular hypertrophy, abnormal myocardial global longitudinal strain with relative apical sparing, biatrial dilation, and small pericardial effusion along with conduction abnormalities. Amyloid deposits leading to hemodynamically significant valvular heart disease are very rare. We describe a rare case of concomitant moderately severe tricuspid and mitral valve stenosis because of ongoing amyloid deposition in a patient with progressive multiple myeloma and fat pad biopsy‐proven light chain amyloidosis. Worsening infiltrative cardiomyopathy and valvulopathy despite evidence‐based chemotherapy and heart failure pharmacotherapy led to end‐stage disease and death. Valvular involvement in cardiac amyloidosis requires early recognition of the underlying disease condition to guide directed medical therapy and prevent its progression. In this instance, valvuloplasty or valve replacement is not a viable option. |
| format | Article |
| id | doaj-art-f886690220434d19bfcf7056aa1c10b8 |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-f886690220434d19bfcf7056aa1c10b82025-02-03T10:25:46ZengWileyESC Heart Failure2055-58222020-06-01731130113510.1002/ehf2.12668Mitral and tricuspid stenosis caused by light chain cardiac amyloid depositionVarinder K. Randhawa0Sneha Vakamudi1Dermot M. Phelan2Christy J. Samaras3Jesse K. McKenney4Mazen Hanna5Antonio L. Perez6Department of Cardiovascular Medicine Cleveland Clinic Cleveland OH 44195 USADepartment of Cardiovascular Medicine Cleveland Clinic Cleveland OH 44195 USADepartment of Cardiovascular Medicine Cleveland Clinic Cleveland OH 44195 USADepartment of Hematology and Oncology Cleveland Clinic 9500 Euclid Ave, Desk J3‐4 Cleveland OH 44195 USADepartment of Pathology Cleveland Clinic 9500 Euclid Avenue Cleveland OH 44195 USADepartment of Cardiovascular Medicine Cleveland Clinic Cleveland OH 44195 USADepartment of Cardiovascular Medicine Cleveland Clinic Cleveland OH 44195 USAAbstract Cardiac amyloidosis results in an infiltrative restrictive cardiomyopathy, with a number of characteristic features: biventricular hypertrophy, abnormal myocardial global longitudinal strain with relative apical sparing, biatrial dilation, and small pericardial effusion along with conduction abnormalities. Amyloid deposits leading to hemodynamically significant valvular heart disease are very rare. We describe a rare case of concomitant moderately severe tricuspid and mitral valve stenosis because of ongoing amyloid deposition in a patient with progressive multiple myeloma and fat pad biopsy‐proven light chain amyloidosis. Worsening infiltrative cardiomyopathy and valvulopathy despite evidence‐based chemotherapy and heart failure pharmacotherapy led to end‐stage disease and death. Valvular involvement in cardiac amyloidosis requires early recognition of the underlying disease condition to guide directed medical therapy and prevent its progression. In this instance, valvuloplasty or valve replacement is not a viable option.https://doi.org/10.1002/ehf2.12668Light chain amyloid valvulopathyLight chain cardiac amyloidosisMitral stenosisTricuspid stenosis |
| spellingShingle | Varinder K. Randhawa Sneha Vakamudi Dermot M. Phelan Christy J. Samaras Jesse K. McKenney Mazen Hanna Antonio L. Perez Mitral and tricuspid stenosis caused by light chain cardiac amyloid deposition ESC Heart Failure Light chain amyloid valvulopathy Light chain cardiac amyloidosis Mitral stenosis Tricuspid stenosis |
| title | Mitral and tricuspid stenosis caused by light chain cardiac amyloid deposition |
| title_full | Mitral and tricuspid stenosis caused by light chain cardiac amyloid deposition |
| title_fullStr | Mitral and tricuspid stenosis caused by light chain cardiac amyloid deposition |
| title_full_unstemmed | Mitral and tricuspid stenosis caused by light chain cardiac amyloid deposition |
| title_short | Mitral and tricuspid stenosis caused by light chain cardiac amyloid deposition |
| title_sort | mitral and tricuspid stenosis caused by light chain cardiac amyloid deposition |
| topic | Light chain amyloid valvulopathy Light chain cardiac amyloidosis Mitral stenosis Tricuspid stenosis |
| url | https://doi.org/10.1002/ehf2.12668 |
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