P62 inhibits IL-1β release during Salmonella Typhimurium infection of macrophages

P62 inhibits IL-1β release during Salmonella Typhimurium infection of macrophages

Macrophages are critical for the innate immune defense against the facultative intracellular Gram-negative bacterium Salmo\nella enterica serovar Typhimurium. Following phagocytosis by macrophages, S. Typhimurium activates cytoplasmic NLRC3 and NLRP4 inflammasomes, which share the adaptor ASC, resul...

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Bibliographic Details
Main Authors: Nina Judith Hos, Julia Fischer, Ambika M. V. Murthy, Zahra Hejazi, Martin Krönke, Deniz Hos, Nirmal Robinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
p62
ASC
IL-1β
IL-10
IFN-I
IFN-β
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1495567/full
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