Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands
Four cationic ruthenium(II) complexes with the formula [Ru(η5-C5H5)(PPh3)2]+, with L=5-phenyl-1H-tetrazole (TzH) 1, imidazole (ImH) 2, benzo[1,2-b;4,3-b′] dithio-phen-2-carbonitrile (Bzt) 3, and [5-(2-thiophen-2-yl)-vinyl]-thiophene-2-carbonitrile] (Tvt) 4 were prepared and characterized in view t...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2010/936834 |
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| author | Virtudes Moreno Julia Lorenzo Francesc X. Aviles M. Helena Garcia João P. Ribeiro Tânia S. Morais Pedro Florindo M. Paula Robalo |
| author_facet | Virtudes Moreno Julia Lorenzo Francesc X. Aviles M. Helena Garcia João P. Ribeiro Tânia S. Morais Pedro Florindo M. Paula Robalo |
| author_sort | Virtudes Moreno |
| collection | DOAJ |
| description | Four cationic ruthenium(II) complexes with the formula [Ru(η5-C5H5)(PPh3)2]+, with L=5-phenyl-1H-tetrazole (TzH) 1, imidazole (ImH) 2, benzo[1,2-b;4,3-b′] dithio-phen-2-carbonitrile (Bzt) 3, and [5-(2-thiophen-2-yl)-vinyl]-thiophene-2-carbonitrile] (Tvt) 4 were prepared and characterized in view to evaluate their potentialities as antitumor agents. Studies by Circular Dichroism indicated changes in the secondary structure of ct-DNA. Changes in the tertiary structure of pBR322 plasmid DNA were also observed in gel electrophoresis experiment and the images obtained by atomic force microscopy (AFM) suggest strong interaction with pBR322 plasmid DNA; the observed decreasing of the viscosity with time indicates that the complexes do not intercalate between DNA base pairs. Compounds 1, 2, and 3 showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells). |
| format | Article |
| id | doaj-art-f876ae6cf9db46a9a701a13c946b6be7 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-f876ae6cf9db46a9a701a13c946b6be72025-02-03T00:59:55ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2010-01-01201010.1155/2010/936834936834Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated LigandsVirtudes Moreno0Julia Lorenzo1Francesc X. Aviles2M. Helena Garcia3João P. Ribeiro4Tânia S. Morais5Pedro Florindo6M. Paula Robalo7Department de Química Inorgànica, Universitat de Barcelona, Martí y Franquès 1-11, 08028 Barcelona, SpainInstitut de Biotecnologia i de Biomedecina, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, SpainInstitut de Biotecnologia i de Biomedecina, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, SpainCentro de Ciências Moleculares e Materiais, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, PortugalCentro de Ciências Moleculares e Materiais, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, PortugalCentro de Ciências Moleculares e Materiais, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, PortugalCentro de Ciências Moleculares e Materiais, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, PortugalCentro de Química Estrutural, Complexo I, Instituto Superior Técnico, Avenue Rovisco Pais, 1049-001 Lisboa, PortugalFour cationic ruthenium(II) complexes with the formula [Ru(η5-C5H5)(PPh3)2]+, with L=5-phenyl-1H-tetrazole (TzH) 1, imidazole (ImH) 2, benzo[1,2-b;4,3-b′] dithio-phen-2-carbonitrile (Bzt) 3, and [5-(2-thiophen-2-yl)-vinyl]-thiophene-2-carbonitrile] (Tvt) 4 were prepared and characterized in view to evaluate their potentialities as antitumor agents. Studies by Circular Dichroism indicated changes in the secondary structure of ct-DNA. Changes in the tertiary structure of pBR322 plasmid DNA were also observed in gel electrophoresis experiment and the images obtained by atomic force microscopy (AFM) suggest strong interaction with pBR322 plasmid DNA; the observed decreasing of the viscosity with time indicates that the complexes do not intercalate between DNA base pairs. Compounds 1, 2, and 3 showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells).http://dx.doi.org/10.1155/2010/936834 |
| spellingShingle | Virtudes Moreno Julia Lorenzo Francesc X. Aviles M. Helena Garcia João P. Ribeiro Tânia S. Morais Pedro Florindo M. Paula Robalo Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands Bioinorganic Chemistry and Applications |
| title | Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands |
| title_full | Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands |
| title_fullStr | Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands |
| title_full_unstemmed | Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands |
| title_short | Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands |
| title_sort | studies of the antiproliferative activity of ruthenium ii cyclopentadienyl derived complexes with nitrogen coordinated ligands |
| url | http://dx.doi.org/10.1155/2010/936834 |
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