Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis
Innate lymphoid cells (ILCs), identified in the early years of this century as a new class of leukocyte family unlike the B or T lymphocytes, play a unique role bridging the innate and adaptive immune responses in mucosal immunity. Their origin, differentiation, and activation process and functions...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/2525984 |
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| _version_ | 1832554329260687360 |
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| author | Hui Fan Aiyun Wang Yuan Wang Ye Sun Jing Han Wenxing Chen Shijun Wang Yuanyuan Wu Yin Lu |
| author_facet | Hui Fan Aiyun Wang Yuan Wang Ye Sun Jing Han Wenxing Chen Shijun Wang Yuanyuan Wu Yin Lu |
| author_sort | Hui Fan |
| collection | DOAJ |
| description | Innate lymphoid cells (ILCs), identified in the early years of this century as a new class of leukocyte family unlike the B or T lymphocytes, play a unique role bridging the innate and adaptive immune responses in mucosal immunity. Their origin, differentiation, and activation process and functions have caught global interest. Recently, accumulating evidence supports that ILCs are vital regulators for gastrointestinal mucosal homeostasis through interactions with other structural and stromal cells in gut epithelial barriers. This review will explore the functions of ILCs and other cells in maintaining gut homeostasis and feature the crosstalk between ILCs with other cells and potential pharmacotherapy targeting ILCs applicable in intestinal innate immunity. |
| format | Article |
| id | doaj-art-f871655c089b466ca2301bd84f3fc73b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f871655c089b466ca2301bd84f3fc73b2025-02-03T05:51:54ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/25259842525984Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune HomeostasisHui Fan0Aiyun Wang1Yuan Wang2Ye Sun3Jing Han4Wenxing Chen5Shijun Wang6Yuanyuan Wu7Yin Lu8Jiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaShandong Co-Innovation Center of TCM Formula, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong 250035, ChinaJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaJiangsu Key Laboratory for Efficacy and Safety Evaluation of Chinese Material Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaInnate lymphoid cells (ILCs), identified in the early years of this century as a new class of leukocyte family unlike the B or T lymphocytes, play a unique role bridging the innate and adaptive immune responses in mucosal immunity. Their origin, differentiation, and activation process and functions have caught global interest. Recently, accumulating evidence supports that ILCs are vital regulators for gastrointestinal mucosal homeostasis through interactions with other structural and stromal cells in gut epithelial barriers. This review will explore the functions of ILCs and other cells in maintaining gut homeostasis and feature the crosstalk between ILCs with other cells and potential pharmacotherapy targeting ILCs applicable in intestinal innate immunity.http://dx.doi.org/10.1155/2019/2525984 |
| spellingShingle | Hui Fan Aiyun Wang Yuan Wang Ye Sun Jing Han Wenxing Chen Shijun Wang Yuanyuan Wu Yin Lu Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis Journal of Immunology Research |
| title | Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis |
| title_full | Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis |
| title_fullStr | Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis |
| title_full_unstemmed | Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis |
| title_short | Innate Lymphoid Cells: Regulators of Gut Barrier Function and Immune Homeostasis |
| title_sort | innate lymphoid cells regulators of gut barrier function and immune homeostasis |
| url | http://dx.doi.org/10.1155/2019/2525984 |
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