Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks

Pancreatic ductal adenocarcinoma (PDAC) is still the Achilles heel in modern oncology, with an increasing incidence accompanied by a persisting high mortality. The developmental process of PDAC is thought to be stepwise via precursor lesions and sequential accumulation of mutations. Thereby, current...

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Bibliographic Details
Main Authors: Lukas Perkhofer, Melanie Engler, Johann Gout, Frank Arnold, Mareen Morawe, Markus Breunig, Thomas Seufferlein, Alexander Kleger, Pierre-Olivier Frappart
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2019/2079742
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