In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases
Muscular dystrophies, myopathies, and traumatic muscle injury and loss encompass a large group of conditions that currently have no cure. Myoblast transplantations have been investigated as potential cures for these conditions for decades. However, current techniques lack the ability to generate cel...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/3027520 |
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| _version_ | 1832549903324151808 |
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| author | Neeladri Chowdhury Atsushi Asakura |
| author_facet | Neeladri Chowdhury Atsushi Asakura |
| author_sort | Neeladri Chowdhury |
| collection | DOAJ |
| description | Muscular dystrophies, myopathies, and traumatic muscle injury and loss encompass a large group of conditions that currently have no cure. Myoblast transplantations have been investigated as potential cures for these conditions for decades. However, current techniques lack the ability to generate cell numbers required to produce any therapeutic benefit. In utero stem cell transplantation into embryos has been studied for many years mainly in the context of hematopoietic cells and has shown to have experimental advantages and therapeutic applications. Moreover, patient-derived cells can be used for experimental transplantation into nonhuman animal embryos via in utero injection as the immune response is absent at such early stages of development. We therefore propose in utero transplantation as a potential method to generate patient-derived humanized skeletal muscle as well as muscle stem cells in animals for therapeutic purposes as well as patient-specific drug screening. |
| format | Article |
| id | doaj-art-f857b19c6ceb45af9d46f573805ed5af |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f857b19c6ceb45af9d46f573805ed5af2025-02-03T06:08:24ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/30275203027520In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle DiseasesNeeladri Chowdhury0Atsushi Asakura1Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USAStem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USAMuscular dystrophies, myopathies, and traumatic muscle injury and loss encompass a large group of conditions that currently have no cure. Myoblast transplantations have been investigated as potential cures for these conditions for decades. However, current techniques lack the ability to generate cell numbers required to produce any therapeutic benefit. In utero stem cell transplantation into embryos has been studied for many years mainly in the context of hematopoietic cells and has shown to have experimental advantages and therapeutic applications. Moreover, patient-derived cells can be used for experimental transplantation into nonhuman animal embryos via in utero injection as the immune response is absent at such early stages of development. We therefore propose in utero transplantation as a potential method to generate patient-derived humanized skeletal muscle as well as muscle stem cells in animals for therapeutic purposes as well as patient-specific drug screening.http://dx.doi.org/10.1155/2017/3027520 |
| spellingShingle | Neeladri Chowdhury Atsushi Asakura In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases Stem Cells International |
| title | In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases |
| title_full | In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases |
| title_fullStr | In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases |
| title_full_unstemmed | In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases |
| title_short | In Utero Stem Cell Transplantation: Potential Therapeutic Application for Muscle Diseases |
| title_sort | in utero stem cell transplantation potential therapeutic application for muscle diseases |
| url | http://dx.doi.org/10.1155/2017/3027520 |
| work_keys_str_mv | AT neeladrichowdhury inuterostemcelltransplantationpotentialtherapeuticapplicationformusclediseases AT atsushiasakura inuterostemcelltransplantationpotentialtherapeuticapplicationformusclediseases |