Influence of Blood Vessels on Temperature during High-Intensity Focused Ultrasound Hyperthermia Based on the Thermal Wave Model of Bioheat Transfer
The coupled effects of blood vessels and thermal relaxation time on temperature and thermal lesion region in biological tissue during high-intensity focused ultrasound (HIFU) hyperthermia are numerically investigated. Considering the non-Fourier behavior of heat conduction in biological tissue, the...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Advances in Condensed Matter Physics |
| Online Access: | http://dx.doi.org/10.1155/2018/5018460 |
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| author | Qiaolai Tan Xiao Zou Hu Dong Yajun Ding Xinmin Zhao |
| author_facet | Qiaolai Tan Xiao Zou Hu Dong Yajun Ding Xinmin Zhao |
| author_sort | Qiaolai Tan |
| collection | DOAJ |
| description | The coupled effects of blood vessels and thermal relaxation time on temperature and thermal lesion region in biological tissue during high-intensity focused ultrasound (HIFU) hyperthermia are numerically investigated. Considering the non-Fourier behavior of heat conduction in biological tissue, the traditional Pennes bioheat equation was modified to thermal wave model of bioheat transfer (TWMBT). Consequently, a joint physical model, which combines TWMBT for tissue and energy transport equation for blood vessel, is presented to predict the evolution of temperature and the thermal lesion region. In this study, pulsatile blood flow is first introduced into numerical study of HIFU hyperthermia, and thermal relaxation time, ultrasonic focus location, blood vessel radius, and blood flow velocity are all taken into account. The results show that the thermal relaxation time plays a key role in the temperature and the thermal lesion region. Larger thermal relaxation time results in lower temperature and smaller thermal lesion region, which indicates that TWMBT leads to lower temperature and smaller thermal lesion region compared to Pennes bioheat transfer model. In addition, we found that the ultrasonic focus location and blood vessel radius significantly affected the temperature and thermal lesion region, while the heartbeat frequency and amplitude factor of pulsating blood flow as well as the average velocity of blood flow had only a slight effect. |
| format | Article |
| id | doaj-art-f83e6b2331144bacb58dc033946bf530 |
| institution | Kabale University |
| issn | 1687-8108 1687-8124 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Condensed Matter Physics |
| spelling | doaj-art-f83e6b2331144bacb58dc033946bf5302025-02-03T01:32:45ZengWileyAdvances in Condensed Matter Physics1687-81081687-81242018-01-01201810.1155/2018/50184605018460Influence of Blood Vessels on Temperature during High-Intensity Focused Ultrasound Hyperthermia Based on the Thermal Wave Model of Bioheat TransferQiaolai Tan0Xiao Zou1Hu Dong2Yajun Ding3Xinmin Zhao4School of Physics and Electronics, Hunan Normal University, Changsha 410081, ChinaSchool of Physics and Electronics, Hunan Normal University, Changsha 410081, ChinaSchool of Physics and Electronics, Hunan Normal University, Changsha 410081, ChinaCollege of Information Science and Engineering, Hunan Normal University, Changsha 410081, ChinaSchool of Physics and Electronics, Hunan Normal University, Changsha 410081, ChinaThe coupled effects of blood vessels and thermal relaxation time on temperature and thermal lesion region in biological tissue during high-intensity focused ultrasound (HIFU) hyperthermia are numerically investigated. Considering the non-Fourier behavior of heat conduction in biological tissue, the traditional Pennes bioheat equation was modified to thermal wave model of bioheat transfer (TWMBT). Consequently, a joint physical model, which combines TWMBT for tissue and energy transport equation for blood vessel, is presented to predict the evolution of temperature and the thermal lesion region. In this study, pulsatile blood flow is first introduced into numerical study of HIFU hyperthermia, and thermal relaxation time, ultrasonic focus location, blood vessel radius, and blood flow velocity are all taken into account. The results show that the thermal relaxation time plays a key role in the temperature and the thermal lesion region. Larger thermal relaxation time results in lower temperature and smaller thermal lesion region, which indicates that TWMBT leads to lower temperature and smaller thermal lesion region compared to Pennes bioheat transfer model. In addition, we found that the ultrasonic focus location and blood vessel radius significantly affected the temperature and thermal lesion region, while the heartbeat frequency and amplitude factor of pulsating blood flow as well as the average velocity of blood flow had only a slight effect.http://dx.doi.org/10.1155/2018/5018460 |
| spellingShingle | Qiaolai Tan Xiao Zou Hu Dong Yajun Ding Xinmin Zhao Influence of Blood Vessels on Temperature during High-Intensity Focused Ultrasound Hyperthermia Based on the Thermal Wave Model of Bioheat Transfer Advances in Condensed Matter Physics |
| title | Influence of Blood Vessels on Temperature during High-Intensity Focused Ultrasound Hyperthermia Based on the Thermal Wave Model of Bioheat Transfer |
| title_full | Influence of Blood Vessels on Temperature during High-Intensity Focused Ultrasound Hyperthermia Based on the Thermal Wave Model of Bioheat Transfer |
| title_fullStr | Influence of Blood Vessels on Temperature during High-Intensity Focused Ultrasound Hyperthermia Based on the Thermal Wave Model of Bioheat Transfer |
| title_full_unstemmed | Influence of Blood Vessels on Temperature during High-Intensity Focused Ultrasound Hyperthermia Based on the Thermal Wave Model of Bioheat Transfer |
| title_short | Influence of Blood Vessels on Temperature during High-Intensity Focused Ultrasound Hyperthermia Based on the Thermal Wave Model of Bioheat Transfer |
| title_sort | influence of blood vessels on temperature during high intensity focused ultrasound hyperthermia based on the thermal wave model of bioheat transfer |
| url | http://dx.doi.org/10.1155/2018/5018460 |
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