Female genital tract microbiome: the influence of probiotics on assisted reproduction
Abstract Assisted reproductive technology (ART) has been evolving since 1978, with the number of techniques performed increasing over the years. Despite continued advances, some couples continue to have difficulties getting pregnant, and it has recently been considered that the microbiome of the fem...
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| Format: | Article |
| Language: | English |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2025-01-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100322&lng=en&tlng=en |
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| _version_ | 1832592612037492736 |
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| author | Ana Sofia Almeida Santana Ana Margarida Póvoa |
| author_facet | Ana Sofia Almeida Santana Ana Margarida Póvoa |
| author_sort | Ana Sofia Almeida Santana |
| collection | DOAJ |
| description | Abstract Assisted reproductive technology (ART) has been evolving since 1978, with the number of techniques performed increasing over the years. Despite continued advances, some couples continue to have difficulties getting pregnant, and it has recently been considered that the microbiome of the female genital tract (FGT) may influence embryo implantation and the establishment of pregnancy. This review aims to evaluate the role of probiotics on reproductive outcomes in infertile women on ART. A search throughout medical databases was performed, and six articles met the criteria. Five studies showed improvements in pregnancy rates, with only one demonstrating statistical significance. One article showed no improvement but reported a statistically significant reduction in the miscarriage rate in the probiotic group. Further research is needed to evaluate the true potential of probiotics, namely to assess whether they effectively modulate the FGT microbiome and if these changes are maintained over time. |
| format | Article |
| id | doaj-art-f83abeb7c6af44449eab75972d6205b8 |
| institution | Kabale University |
| issn | 0100-7203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj-art-f83abeb7c6af44449eab75972d6205b82025-01-21T07:36:28ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032025-01-014610.61622/rbgo/2024rbgo82Female genital tract microbiome: the influence of probiotics on assisted reproductionAna Sofia Almeida Santanahttps://orcid.org/0009-0004-8516-406XAna Margarida Póvoahttps://orcid.org/0000-0003-0018-9264Abstract Assisted reproductive technology (ART) has been evolving since 1978, with the number of techniques performed increasing over the years. Despite continued advances, some couples continue to have difficulties getting pregnant, and it has recently been considered that the microbiome of the female genital tract (FGT) may influence embryo implantation and the establishment of pregnancy. This review aims to evaluate the role of probiotics on reproductive outcomes in infertile women on ART. A search throughout medical databases was performed, and six articles met the criteria. Five studies showed improvements in pregnancy rates, with only one demonstrating statistical significance. One article showed no improvement but reported a statistically significant reduction in the miscarriage rate in the probiotic group. Further research is needed to evaluate the true potential of probiotics, namely to assess whether they effectively modulate the FGT microbiome and if these changes are maintained over time.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100322&lng=en&tlng=enPregnancy outcomeInfertility, femaleAbortion, spontaneousPregnancy rateGenitalia, femaleEmbryo implantationReproductive techniques, assisted, MicrobiotaProbiotics |
| spellingShingle | Ana Sofia Almeida Santana Ana Margarida Póvoa Female genital tract microbiome: the influence of probiotics on assisted reproduction Revista Brasileira de Ginecologia e Obstetrícia Pregnancy outcome Infertility, female Abortion, spontaneous Pregnancy rate Genitalia, female Embryo implantation Reproductive techniques, assisted, Microbiota Probiotics |
| title | Female genital tract microbiome: the influence of probiotics on assisted reproduction |
| title_full | Female genital tract microbiome: the influence of probiotics on assisted reproduction |
| title_fullStr | Female genital tract microbiome: the influence of probiotics on assisted reproduction |
| title_full_unstemmed | Female genital tract microbiome: the influence of probiotics on assisted reproduction |
| title_short | Female genital tract microbiome: the influence of probiotics on assisted reproduction |
| title_sort | female genital tract microbiome the influence of probiotics on assisted reproduction |
| topic | Pregnancy outcome Infertility, female Abortion, spontaneous Pregnancy rate Genitalia, female Embryo implantation Reproductive techniques, assisted, Microbiota Probiotics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100322&lng=en&tlng=en |
| work_keys_str_mv | AT anasofiaalmeidasantana femalegenitaltractmicrobiometheinfluenceofprobioticsonassistedreproduction AT anamargaridapovoa femalegenitaltractmicrobiometheinfluenceofprobioticsonassistedreproduction |