Acute ischaemia and gap junction modulation modify propagation patterns across Purkinje-myocardial junctions

Acute ischaemia and gap junction modulation modify propagation patterns across Purkinje-myocardial junctions

BackgroundThe Purkinje network is essential for normal electrical impulse propagation in the heart but has also been implicated in ventricular arrhythmias. Previous experimental work has suggested that not all Purkinje-myocardial junctions (PMJs) are active at rest due to source-sink mismatch at the...

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Main Authors:	Richard J. Jabbour, Elham Behradfar, Michael Debney, Anders Nygren, Adam Hartley, Igor Efimov, Mélèze Hocini, Nicholas S. Peters, Fu Siong Ng, Edward J. Vigmond
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Physiology
Subjects:	purkinje system Purkinje-myocardial junction ischaemia computer modelling cardiac electrophysiology
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2025.1540400/full
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