STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone
Background. In our previous study, mouse double minute 2 homolog (MDM2), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription 1 (STAT1), and Rac family small GTPase 1 (RAC1) were correlated with the recurrence of giant cell tumor of bone (GCT). The aim of this study...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/4564328 |
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| author | Shuxin Chen Zepeng Du Bingli Wu Huiyang Shen Chunpeng Liu Xueli Qiu Yufeng Zhang Liyan Xu Enmin Li Zhigang Zhong |
| author_facet | Shuxin Chen Zepeng Du Bingli Wu Huiyang Shen Chunpeng Liu Xueli Qiu Yufeng Zhang Liyan Xu Enmin Li Zhigang Zhong |
| author_sort | Shuxin Chen |
| collection | DOAJ |
| description | Background. In our previous study, mouse double minute 2 homolog (MDM2), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription 1 (STAT1), and Rac family small GTPase 1 (RAC1) were correlated with the recurrence of giant cell tumor of bone (GCT). The aim of this study is to use a large cohort study to confirm the involvement of these four genes in GCT recurrence. Methods. The expression of these four genes was detected and compared between GCT patients with or without recurrence. The correlation between the expression of these four genes and clinical characteristics was evaluated. Protein-protein interaction (PPI) network was constructed for functional enrichment analysis. Results. It showed that the expression levels of MDM2, IGF1, STAT1, and RAC1 in GCT patients with recurrence were significantly higher than those in GCT patients without recurrence (P<0.05). Multivariate logistic regression analysis suggested that several clinical characteristics may influence prognosis. A PPI network was constructed using the four genes as hub genes. Functional enrichment analysis showed that this network involves many important biological progress mediated by these four genes, including immune response. Conclusion. MDM2, IGF1, STAT1, and RAC1 are associated with GCT recurrence, which might serve as biomarkers for GCT recurrence. |
| format | Article |
| id | doaj-art-f836c204dbec42c08874e1252d6759a3 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f836c204dbec42c08874e1252d6759a32025-02-03T01:10:30ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/45643284564328STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of BoneShuxin Chen0Zepeng Du1Bingli Wu2Huiyang Shen3Chunpeng Liu4Xueli Qiu5Yufeng Zhang6Liyan Xu7Enmin Li8Zhigang Zhong9Department of Orthopedic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, ChinaDepartment of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Orthopedic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, ChinaDepartment of Orthopedic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, ChinaDepartment of Orthopedic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, ChinaDepartment of Orthopedic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, ChinaInstitute of Oncologic Pathology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, ChinaDepartment of Orthopedic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou 515041, ChinaBackground. In our previous study, mouse double minute 2 homolog (MDM2), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription 1 (STAT1), and Rac family small GTPase 1 (RAC1) were correlated with the recurrence of giant cell tumor of bone (GCT). The aim of this study is to use a large cohort study to confirm the involvement of these four genes in GCT recurrence. Methods. The expression of these four genes was detected and compared between GCT patients with or without recurrence. The correlation between the expression of these four genes and clinical characteristics was evaluated. Protein-protein interaction (PPI) network was constructed for functional enrichment analysis. Results. It showed that the expression levels of MDM2, IGF1, STAT1, and RAC1 in GCT patients with recurrence were significantly higher than those in GCT patients without recurrence (P<0.05). Multivariate logistic regression analysis suggested that several clinical characteristics may influence prognosis. A PPI network was constructed using the four genes as hub genes. Functional enrichment analysis showed that this network involves many important biological progress mediated by these four genes, including immune response. Conclusion. MDM2, IGF1, STAT1, and RAC1 are associated with GCT recurrence, which might serve as biomarkers for GCT recurrence.http://dx.doi.org/10.1155/2018/4564328 |
| spellingShingle | Shuxin Chen Zepeng Du Bingli Wu Huiyang Shen Chunpeng Liu Xueli Qiu Yufeng Zhang Liyan Xu Enmin Li Zhigang Zhong STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone Journal of Immunology Research |
| title | STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone |
| title_full | STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone |
| title_fullStr | STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone |
| title_full_unstemmed | STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone |
| title_short | STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone |
| title_sort | stat1 igf1 rac1 and mdm2 are associated with recurrence of giant cell tumor of bone |
| url | http://dx.doi.org/10.1155/2018/4564328 |
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