An Evaluation of Cellulose Hydrogels Derived from <i>tequilana</i> Weber Bagasse for the Regeneration of Gingival Connective Tissue in Lagomorphs
Cellulose hydrogels derived from agave bagasse were formulated to promote the regeneration of gingival connective tissue in lagomorphs. Three treatment modalities were randomly implanted in the gingival diastema area in 16 rabbits. The general characteristics were analyzed and histopathological stud...
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2025-01-01
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| author | Silvia López-Domínguez Juan Carlos Cuevas-González León Francisco Espinosa-Cristóbal Judith Virginia Ríos-Arana Rosa Alicia Saucedo Acuña María Verónica Cuevas-González Erasto Armando Zaragoza-Contreras Karla Lizette Tovar Carrillo |
| author_facet | Silvia López-Domínguez Juan Carlos Cuevas-González León Francisco Espinosa-Cristóbal Judith Virginia Ríos-Arana Rosa Alicia Saucedo Acuña María Verónica Cuevas-González Erasto Armando Zaragoza-Contreras Karla Lizette Tovar Carrillo |
| author_sort | Silvia López-Domínguez |
| collection | DOAJ |
| description | Cellulose hydrogels derived from agave bagasse were formulated to promote the regeneration of gingival connective tissue in lagomorphs. Three treatment modalities were randomly implanted in the gingival diastema area in 16 rabbits. The general characteristics were analyzed and histopathological studies were carried out at 4, 8, 12, and 16 weeks. A chi-squared test was performed using IBM-SPSS version 25, indicating that cellulose hydrogels implanted in lagomorph’s gingival tissue showed the presence of greater angiogenesis and fibrogenesis at the four evaluation intervals during 16 consecutive weeks. The presence of inflammatory infiltrates had no significant impact. No significant changes were observed in body weight and water and food intake. This suggests that hydrogels contribute to the regeneration and/or repair of oral connective tissue, showing angiogenesis and fibrogenesis in 50 to 100% of rabbits tested with hydrogel cellulose membrane. Regarding angiogenesis, in the specimens where membranes were implanted, its presence predominated in all variants (50%), followed by diffuse angiogenesis (37.5%), and finally the absence of angiogenesis (12.5%). |
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| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Gels |
| spelling | doaj-art-f82b239cd1b945c489b1b915bb0ed1072025-01-24T13:34:02ZengMDPI AGGels2310-28612025-01-011117510.3390/gels11010075An Evaluation of Cellulose Hydrogels Derived from <i>tequilana</i> Weber Bagasse for the Regeneration of Gingival Connective Tissue in LagomorphsSilvia López-Domínguez0Juan Carlos Cuevas-González1León Francisco Espinosa-Cristóbal2Judith Virginia Ríos-Arana3Rosa Alicia Saucedo Acuña4María Verónica Cuevas-González5Erasto Armando Zaragoza-Contreras6Karla Lizette Tovar Carrillo7Instituto de Ciencias Biomédicas, Universidad Autónoma de Cd. Juárez, Av. Benjamín Franklin # 4960 Zona Pronaf. Cd. Juárez, Chihuahua C.P. 32315, MexicoInstituto de Ciencias Biomédicas, Universidad Autónoma de Cd. Juárez, Av. Benjamín Franklin # 4960 Zona Pronaf. Cd. Juárez, Chihuahua C.P. 32315, MexicoInstituto de Ciencias Biomédicas, Universidad Autónoma de Cd. Juárez, Av. Benjamín Franklin # 4960 Zona Pronaf. Cd. Juárez, Chihuahua C.P. 32315, MexicoInstituto de Ciencias Biomédicas, Universidad Autónoma de Cd. Juárez, Av. Benjamín Franklin # 4960 Zona Pronaf. Cd. Juárez, Chihuahua C.P. 32315, MexicoInstituto de Ciencias Biomédicas, Universidad Autónoma de Cd. Juárez, Av. Benjamín Franklin # 4960 Zona Pronaf. Cd. Juárez, Chihuahua C.P. 32315, MexicoInstituto de Ciencias Biomédicas, Universidad Autónoma de Cd. Juárez, Av. Benjamín Franklin # 4960 Zona Pronaf. Cd. Juárez, Chihuahua C.P. 32315, MexicoCentro de Investigación en Materiales Avanzados, S.C. Miguel de Cervantes No. 180, Complejo Industrial Chihuahua, Chihuahua C.P. 31136, MexicoInstituto de Ciencias Biomédicas, Universidad Autónoma de Cd. Juárez, Av. Benjamín Franklin # 4960 Zona Pronaf. Cd. Juárez, Chihuahua C.P. 32315, MexicoCellulose hydrogels derived from agave bagasse were formulated to promote the regeneration of gingival connective tissue in lagomorphs. Three treatment modalities were randomly implanted in the gingival diastema area in 16 rabbits. The general characteristics were analyzed and histopathological studies were carried out at 4, 8, 12, and 16 weeks. A chi-squared test was performed using IBM-SPSS version 25, indicating that cellulose hydrogels implanted in lagomorph’s gingival tissue showed the presence of greater angiogenesis and fibrogenesis at the four evaluation intervals during 16 consecutive weeks. The presence of inflammatory infiltrates had no significant impact. No significant changes were observed in body weight and water and food intake. This suggests that hydrogels contribute to the regeneration and/or repair of oral connective tissue, showing angiogenesis and fibrogenesis in 50 to 100% of rabbits tested with hydrogel cellulose membrane. Regarding angiogenesis, in the specimens where membranes were implanted, its presence predominated in all variants (50%), followed by diffuse angiogenesis (37.5%), and finally the absence of angiogenesis (12.5%).https://www.mdpi.com/2310-2861/11/1/75agave <i>tequilana</i> weberhydrogellagomorphwound healingtissue engineeringbiomaterial |
| spellingShingle | Silvia López-Domínguez Juan Carlos Cuevas-González León Francisco Espinosa-Cristóbal Judith Virginia Ríos-Arana Rosa Alicia Saucedo Acuña María Verónica Cuevas-González Erasto Armando Zaragoza-Contreras Karla Lizette Tovar Carrillo An Evaluation of Cellulose Hydrogels Derived from <i>tequilana</i> Weber Bagasse for the Regeneration of Gingival Connective Tissue in Lagomorphs Gels agave <i>tequilana</i> weber hydrogel lagomorph wound healing tissue engineering biomaterial |
| title | An Evaluation of Cellulose Hydrogels Derived from <i>tequilana</i> Weber Bagasse for the Regeneration of Gingival Connective Tissue in Lagomorphs |
| title_full | An Evaluation of Cellulose Hydrogels Derived from <i>tequilana</i> Weber Bagasse for the Regeneration of Gingival Connective Tissue in Lagomorphs |
| title_fullStr | An Evaluation of Cellulose Hydrogels Derived from <i>tequilana</i> Weber Bagasse for the Regeneration of Gingival Connective Tissue in Lagomorphs |
| title_full_unstemmed | An Evaluation of Cellulose Hydrogels Derived from <i>tequilana</i> Weber Bagasse for the Regeneration of Gingival Connective Tissue in Lagomorphs |
| title_short | An Evaluation of Cellulose Hydrogels Derived from <i>tequilana</i> Weber Bagasse for the Regeneration of Gingival Connective Tissue in Lagomorphs |
| title_sort | evaluation of cellulose hydrogels derived from i tequilana i weber bagasse for the regeneration of gingival connective tissue in lagomorphs |
| topic | agave <i>tequilana</i> weber hydrogel lagomorph wound healing tissue engineering biomaterial |
| url | https://www.mdpi.com/2310-2861/11/1/75 |
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