The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases
The long noncoding RNAs (lncRNAs) are RNA transcripts more than 200 nucleotides in length, which do not encode proteins. The lncRNAs are emerging as an important regulator of biological process, such as chromatin remodeling, gene transcription, protein transport, and trafficking through diverse mech...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/848790 |
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| _version_ | 1832552057373982720 |
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| author | Keshav Raj Sigdel Ao Cheng Yin Wang Lihua Duan YanLin Zhang |
| author_facet | Keshav Raj Sigdel Ao Cheng Yin Wang Lihua Duan YanLin Zhang |
| author_sort | Keshav Raj Sigdel |
| collection | DOAJ |
| description | The long noncoding RNAs (lncRNAs) are RNA transcripts more than 200 nucleotides in length, which do not encode proteins. The lncRNAs are emerging as an important regulator of biological process, such as chromatin remodeling, gene transcription, protein transport, and trafficking through diverse mechanisms. The lncRNAs play crucial role in various multigenetics human diseases including cancers and neurological diseases and currently its role in autoimmune diseases is attracting many researchers. Recent studies have reported that differentiation and activation of immune cells, T cells, B cells, macrophages, and NK cells have correlation with lncRNAs, which have also an essential role in autoimmune diseases such as rheumatoid arthritis and SLE. Therefore, elucidation of the roles of lncRNAs in autoimmunity could be beneficial to understand the pathogenesis of autoimmune diseases. In this review article we attempt to highlight the recent progress regarding lncRNAs studies and summarize its role in autoimmune diseases. |
| format | Article |
| id | doaj-art-f814f627247f46959089267b571d2f8f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f814f627247f46959089267b571d2f8f2025-02-03T05:59:51ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/848790848790The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune DiseasesKeshav Raj Sigdel0Ao Cheng1Yin Wang2Lihua Duan3YanLin Zhang4Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, ChinaDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, ChinaDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, ChinaDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, ChinaDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, ChinaThe long noncoding RNAs (lncRNAs) are RNA transcripts more than 200 nucleotides in length, which do not encode proteins. The lncRNAs are emerging as an important regulator of biological process, such as chromatin remodeling, gene transcription, protein transport, and trafficking through diverse mechanisms. The lncRNAs play crucial role in various multigenetics human diseases including cancers and neurological diseases and currently its role in autoimmune diseases is attracting many researchers. Recent studies have reported that differentiation and activation of immune cells, T cells, B cells, macrophages, and NK cells have correlation with lncRNAs, which have also an essential role in autoimmune diseases such as rheumatoid arthritis and SLE. Therefore, elucidation of the roles of lncRNAs in autoimmunity could be beneficial to understand the pathogenesis of autoimmune diseases. In this review article we attempt to highlight the recent progress regarding lncRNAs studies and summarize its role in autoimmune diseases.http://dx.doi.org/10.1155/2015/848790 |
| spellingShingle | Keshav Raj Sigdel Ao Cheng Yin Wang Lihua Duan YanLin Zhang The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases Journal of Immunology Research |
| title | The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases |
| title_full | The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases |
| title_fullStr | The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases |
| title_full_unstemmed | The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases |
| title_short | The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases |
| title_sort | emerging functions of long noncoding rna in immune cells autoimmune diseases |
| url | http://dx.doi.org/10.1155/2015/848790 |
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