Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes
This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography an...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2016-06-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2016-0021 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832569972507803648 |
|---|---|
| author | Lee Dong-Gi Jang Ik Soon Yang Kyeong Eun Yoon So-Jung Baek Sujeong Lee Joo Yong Suzuki Tatsuro Chung Keun-Yook Woo Sun-Hee Choi Jong-Soon |
| author_facet | Lee Dong-Gi Jang Ik Soon Yang Kyeong Eun Yoon So-Jung Baek Sujeong Lee Joo Yong Suzuki Tatsuro Chung Keun-Yook Woo Sun-Hee Choi Jong-Soon |
| author_sort | Lee Dong-Gi |
| collection | DOAJ |
| description | This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; it is negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes. |
| format | Article |
| id | doaj-art-f812051e1b8c4545a0851c5e58f4d72a |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-f812051e1b8c4545a0851c5e58f4d72a2025-02-02T18:34:47ZengSciendoActa Pharmaceutica1846-95582016-06-0166229730210.1515/acph-2016-0021acph-2016-0021Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetesLee Dong-Gi0Jang Ik Soon1Yang Kyeong Eun2Yoon So-Jung3Baek Sujeong4Lee Joo Yong5Suzuki Tatsuro6Chung Keun-Yook7Woo Sun-Hee8Choi Jong-Soon Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea Drug & Disease Target Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, Republic of Korea Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea National Agricultural Research Center for Hokkaido Region, Memuro, Hokkaido 0820081, Japan Department of Agricultural Chemistry, Chungbuk National University, Cheongju 28644, Republic of Korea Department of Crop Science, Chungbuk National University, Cheongju 28644, Republic of KoreaThis study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; it is negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.https://doi.org/10.1515/acph-2016-0021tartary buckwheat sproutrutintype 2 diabetesinsulin signaling |
| spellingShingle | Lee Dong-Gi Jang Ik Soon Yang Kyeong Eun Yoon So-Jung Baek Sujeong Lee Joo Yong Suzuki Tatsuro Chung Keun-Yook Woo Sun-Hee Choi Jong-Soon Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes Acta Pharmaceutica tartary buckwheat sprout rutin type 2 diabetes insulin signaling |
| title | Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes |
| title_full | Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes |
| title_fullStr | Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes |
| title_full_unstemmed | Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes |
| title_short | Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes |
| title_sort | effect of rutin from tartary buckwheat sprout on serum glucose lowering in animal model of type 2 diabetes |
| topic | tartary buckwheat sprout rutin type 2 diabetes insulin signaling |
| url | https://doi.org/10.1515/acph-2016-0021 |
| work_keys_str_mv | AT leedonggi effectofrutinfromtartarybuckwheatsproutonserumglucoseloweringinanimalmodeloftype2diabetes AT jangiksoon effectofrutinfromtartarybuckwheatsproutonserumglucoseloweringinanimalmodeloftype2diabetes AT yangkyeongeun effectofrutinfromtartarybuckwheatsproutonserumglucoseloweringinanimalmodeloftype2diabetes AT yoonsojung effectofrutinfromtartarybuckwheatsproutonserumglucoseloweringinanimalmodeloftype2diabetes AT baeksujeong effectofrutinfromtartarybuckwheatsproutonserumglucoseloweringinanimalmodeloftype2diabetes AT leejooyong effectofrutinfromtartarybuckwheatsproutonserumglucoseloweringinanimalmodeloftype2diabetes AT suzukitatsuro effectofrutinfromtartarybuckwheatsproutonserumglucoseloweringinanimalmodeloftype2diabetes AT chungkeunyook effectofrutinfromtartarybuckwheatsproutonserumglucoseloweringinanimalmodeloftype2diabetes AT woosunhee effectofrutinfromtartarybuckwheatsproutonserumglucoseloweringinanimalmodeloftype2diabetes AT choijongsoon effectofrutinfromtartarybuckwheatsproutonserumglucoseloweringinanimalmodeloftype2diabetes |