Melatonin and diabetes: from pathophysiology to the treatment perspectives
Pineal hormone melatonin synchronizes insulin secretion and glucose homeostasis with solar periods. Misalliance between melatonin-mediated circadian rhythms and insulin secretion characterizes diabetes mellitus type 1 (T1DM) and type 2 (T2DM). Insulin deficiency in T1DM is accompanied by increased m...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2013-06-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/3751 |
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| author | Vladimir Iosifovich Konenkov Vadim Valerievich Klimontov Svetlana Viktorovna Michurina M A Prudnikova I Ju Ishenko |
| author_facet | Vladimir Iosifovich Konenkov Vadim Valerievich Klimontov Svetlana Viktorovna Michurina M A Prudnikova I Ju Ishenko |
| author_sort | Vladimir Iosifovich Konenkov |
| collection | DOAJ |
| description | Pineal hormone melatonin synchronizes insulin secretion and glucose homeostasis with solar periods. Misalliance between melatonin-mediated circadian rhythms and insulin secretion characterizes diabetes mellitus type 1 (T1DM) and type 2 (T2DM). Insulin deficiency in T1DM is accompanied by increased melatonin production. Conversely, T2DM is characterized by diminished melatonin secretion. In genome-wide association studies the variants of melatonin receptor MT2 gene (rs1387153 and rs10830963) were associated with fasting glucose, beta-cell function and T2DM. In experimental models of diabetes melatonin enhanced beta-cell proliferation and neogenesis, improved insulin resistance and alleviated oxidative stress in retina and kidneys. However, further investigation is required to assess the therapeutic value of melatonin in diabetic patients. |
| format | Article |
| id | doaj-art-f80c0ce67853430aa9b49c6c16d3126c |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2013-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-f80c0ce67853430aa9b49c6c16d3126c2025-08-20T02:29:34ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782013-06-01162111610.14341/2072-0351-37513721Melatonin and diabetes: from pathophysiology to the treatment perspectivesVladimir Iosifovich Konenkov0Vadim Valerievich Klimontov1Svetlana Viktorovna Michurina2M A Prudnikova3I Ju Ishenko4Research Institute of Clinical and Experimental Lymphology, NovosibirskResearch Institute of Clinical and Experimental Lymphology, NovosibirskResearch Institute of Clinical and Experimental Lymphology, NovosibirskResearch Institute of Clinical and Experimental Lymphology, NovosibirskResearch Institute of Clinical and Experimental Lymphology, NovosibirskPineal hormone melatonin synchronizes insulin secretion and glucose homeostasis with solar periods. Misalliance between melatonin-mediated circadian rhythms and insulin secretion characterizes diabetes mellitus type 1 (T1DM) and type 2 (T2DM). Insulin deficiency in T1DM is accompanied by increased melatonin production. Conversely, T2DM is characterized by diminished melatonin secretion. In genome-wide association studies the variants of melatonin receptor MT2 gene (rs1387153 and rs10830963) were associated with fasting glucose, beta-cell function and T2DM. In experimental models of diabetes melatonin enhanced beta-cell proliferation and neogenesis, improved insulin resistance and alleviated oxidative stress in retina and kidneys. However, further investigation is required to assess the therapeutic value of melatonin in diabetic patients.https://www.dia-endojournals.ru/jour/article/view/3751diabetesmelatonincircadian rhythmsinsulinepiphysis |
| spellingShingle | Vladimir Iosifovich Konenkov Vadim Valerievich Klimontov Svetlana Viktorovna Michurina M A Prudnikova I Ju Ishenko Melatonin and diabetes: from pathophysiology to the treatment perspectives Сахарный диабет diabetes melatonin circadian rhythms insulin epiphysis |
| title | Melatonin and diabetes: from pathophysiology to the treatment perspectives |
| title_full | Melatonin and diabetes: from pathophysiology to the treatment perspectives |
| title_fullStr | Melatonin and diabetes: from pathophysiology to the treatment perspectives |
| title_full_unstemmed | Melatonin and diabetes: from pathophysiology to the treatment perspectives |
| title_short | Melatonin and diabetes: from pathophysiology to the treatment perspectives |
| title_sort | melatonin and diabetes from pathophysiology to the treatment perspectives |
| topic | diabetes melatonin circadian rhythms insulin epiphysis |
| url | https://www.dia-endojournals.ru/jour/article/view/3751 |
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