Clinical Outcomes from Unselected “Real-World” Patients with Long Coronary Lesion Receiving 40 mm Biodegradable Polymer Coated Sirolimus-Eluting Stent
Background. Long lesions being implanted with drug-eluting stents (DES) are associated with relatively high restenosis rates and higher incidences of adverse events. Objectives. We aimed to examine the safety and efficacy of the long (40 mm) biodegradable polymer coated Indolimus sirolimus-eluting s...
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Wiley
2015-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2015/613089 |
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| author | Anurag Polavarapu Raghava Sarma Polavarapu Jayesh Prajapati Kamlesh Thakkar Asif Raheem Tamanpreet Mayall Ashok Thakkar |
| author_facet | Anurag Polavarapu Raghava Sarma Polavarapu Jayesh Prajapati Kamlesh Thakkar Asif Raheem Tamanpreet Mayall Ashok Thakkar |
| author_sort | Anurag Polavarapu |
| collection | DOAJ |
| description | Background. Long lesions being implanted with drug-eluting stents (DES) are associated with relatively high restenosis rates and higher incidences of adverse events. Objectives. We aimed to examine the safety and efficacy of the long (40 mm) biodegradable polymer coated Indolimus sirolimus-eluting stent (SES) in real-world patients with long coronary lesions. Methods. This study was observational, nonrandomized, retrospective, and carried out in real-world patients. A total of 258 patients were enrolled for the treatment of long coronary lesions, with 40 mm Indolimus. The primary endpoints in the study were incidence of major adverse cardiac events (MACE), a miscellany of cardiac death, myocardial infarction (MI), target lesion revascularization (TLR) or target vessel revascularization (TVR), and stent thrombosis (ST) up to 6-month follow-up. Results. The study population included higher proportion of males (74.4%) and average age was 53.2 ± 11.0 years. A total of 278 lesions were intervened successfully with 280 stents. The observed MACE at 6-month follow-up was 2.0%, which included 0.8% cardiac death and 1.2% MI. There were no TLR or TVR and ST observed during 6-month follow-up. Conclusions. The long (40 mm) Indolimus stent demonstrated low MACE rate and was proven to be safe and effective treatment for long lesions in “real-world” patients. |
| format | Article |
| id | doaj-art-f80bee1439774ce6af902e3413474f34 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-f80bee1439774ce6af902e3413474f342025-02-03T06:13:57ZengWileyScientifica2090-908X2015-01-01201510.1155/2015/613089613089Clinical Outcomes from Unselected “Real-World” Patients with Long Coronary Lesion Receiving 40 mm Biodegradable Polymer Coated Sirolimus-Eluting StentAnurag Polavarapu0Raghava Sarma Polavarapu1Jayesh Prajapati2Kamlesh Thakkar3Asif Raheem4Tamanpreet Mayall5Ashok Thakkar6Lalitha Super Specialty Hospital Pvt. Ltd., Heart and Brain Centre, Kothapet, Guntur, Andhra Pradesh 522001, IndiaLalitha Super Specialty Hospital Pvt. Ltd., Heart and Brain Centre, Kothapet, Guntur, Andhra Pradesh 522001, IndiaApollo Hospitals, Ahmedabad, Gujarat 382428, IndiaLions Sterling Super Specialty Hospital, Mehsana, Gujarat 384002, IndiaYashfeen Cardiac Hospital, Navsari, Gujarat 396445, IndiaDepartment of Clinical Trials, Sahajanand Medical Technologies Pvt. Ltd., Surat, Gujarat 395004, IndiaDepartment of Clinical Trials, Sahajanand Medical Technologies Pvt. Ltd., Surat, Gujarat 395004, IndiaBackground. Long lesions being implanted with drug-eluting stents (DES) are associated with relatively high restenosis rates and higher incidences of adverse events. Objectives. We aimed to examine the safety and efficacy of the long (40 mm) biodegradable polymer coated Indolimus sirolimus-eluting stent (SES) in real-world patients with long coronary lesions. Methods. This study was observational, nonrandomized, retrospective, and carried out in real-world patients. A total of 258 patients were enrolled for the treatment of long coronary lesions, with 40 mm Indolimus. The primary endpoints in the study were incidence of major adverse cardiac events (MACE), a miscellany of cardiac death, myocardial infarction (MI), target lesion revascularization (TLR) or target vessel revascularization (TVR), and stent thrombosis (ST) up to 6-month follow-up. Results. The study population included higher proportion of males (74.4%) and average age was 53.2 ± 11.0 years. A total of 278 lesions were intervened successfully with 280 stents. The observed MACE at 6-month follow-up was 2.0%, which included 0.8% cardiac death and 1.2% MI. There were no TLR or TVR and ST observed during 6-month follow-up. Conclusions. The long (40 mm) Indolimus stent demonstrated low MACE rate and was proven to be safe and effective treatment for long lesions in “real-world” patients.http://dx.doi.org/10.1155/2015/613089 |
| spellingShingle | Anurag Polavarapu Raghava Sarma Polavarapu Jayesh Prajapati Kamlesh Thakkar Asif Raheem Tamanpreet Mayall Ashok Thakkar Clinical Outcomes from Unselected “Real-World” Patients with Long Coronary Lesion Receiving 40 mm Biodegradable Polymer Coated Sirolimus-Eluting Stent Scientifica |
| title | Clinical Outcomes from Unselected “Real-World” Patients with Long Coronary Lesion Receiving 40 mm Biodegradable Polymer Coated Sirolimus-Eluting Stent |
| title_full | Clinical Outcomes from Unselected “Real-World” Patients with Long Coronary Lesion Receiving 40 mm Biodegradable Polymer Coated Sirolimus-Eluting Stent |
| title_fullStr | Clinical Outcomes from Unselected “Real-World” Patients with Long Coronary Lesion Receiving 40 mm Biodegradable Polymer Coated Sirolimus-Eluting Stent |
| title_full_unstemmed | Clinical Outcomes from Unselected “Real-World” Patients with Long Coronary Lesion Receiving 40 mm Biodegradable Polymer Coated Sirolimus-Eluting Stent |
| title_short | Clinical Outcomes from Unselected “Real-World” Patients with Long Coronary Lesion Receiving 40 mm Biodegradable Polymer Coated Sirolimus-Eluting Stent |
| title_sort | clinical outcomes from unselected real world patients with long coronary lesion receiving 40 mm biodegradable polymer coated sirolimus eluting stent |
| url | http://dx.doi.org/10.1155/2015/613089 |
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