Neutrophil Gelatinase-Associated Lipocalin: A New Marker of Renal Function in C-Related End Stage Liver Disease
Background/Aims. Renal impairment is a common complication of cirrhosis. Serum creatinine is less sensitive in these patients. Measurement of the glomerular filtration rate (GFR) is the gold standard but time consuming. The aim is to validate plasma NGAL (pNGAL) and urinary NGAL (uNGAL) as markers o...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/815484 |
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| author | Omkolsoum Mohamed Alhaddad Ayman Alsebaey Mohamed Omar Amer Hala Hany El-Said Tary Abdel Hamid Salman |
| author_facet | Omkolsoum Mohamed Alhaddad Ayman Alsebaey Mohamed Omar Amer Hala Hany El-Said Tary Abdel Hamid Salman |
| author_sort | Omkolsoum Mohamed Alhaddad |
| collection | DOAJ |
| description | Background/Aims. Renal impairment is a common complication of cirrhosis. Serum creatinine is less sensitive in these patients. Measurement of the glomerular filtration rate (GFR) is the gold standard but time consuming. The aim is to validate plasma NGAL (pNGAL) and urinary NGAL (uNGAL) as markers of renal function in patients with HCV related cirrhosis. Patient and Methods. One hundred HCV related end stage liver cirrhosis patients were randomized into two groups: Group I (n=35), patients with GFR < 60 mL/m measured by isotope scanning of the kidney (Renogram), and Group II (n=65), patients with GFR ≥ 60 mL/m. The pNGAL and uNGAL were measured within 2 days of the Renogram. Results. Both groups were matched with age, sex, and Child Pugh score. There was statistically significant difference between both groups regarding serum creatinine (1.98 ± 1.04 versus 1.38 ± 0.88 mg/dL; p=0.003) and pNGAL level (5.79 ± 2.06 versus 7.25 ± 3.30 ng/dL; p=0.019). Both groups were comparable (p>0.05) for the uNGAL (6.00 ± 0.78 versus 6.03 ± 0.96 ng/mL). Unlike uNGAL, the pNGAL positively correlated with total GFR by Renogram (r=0.3; p=0.001). With a cutoff ≥4 ng/mL, pNGAL had 94.3% sensitivity and 1.5% specificity and PPV = 34, NPV = 33.3, LR+ = −175.1, and LR− = −60.6. Conclusion. The pNGAL is a promising marker of the renal function in patients with cirrhosis. |
| format | Article |
| id | doaj-art-f7f895dfe6cf49e3a68285601ea79685 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-f7f895dfe6cf49e3a68285601ea796852025-02-03T06:06:20ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/815484815484Neutrophil Gelatinase-Associated Lipocalin: A New Marker of Renal Function in C-Related End Stage Liver DiseaseOmkolsoum Mohamed Alhaddad0Ayman Alsebaey1Mohamed Omar Amer2Hala Hany El-Said3Tary Abdel Hamid Salman4Department of Hepatology, National Liver Institute, Menoufiya University, Shebeen El-Kom, EgyptDepartment of Hepatology, National Liver Institute, Menoufiya University, Shebeen El-Kom, EgyptDepartment of Hepatology, National Liver Institute, Menoufiya University, Shebeen El-Kom, EgyptDepartment of Clinical Biochemistry, National Liver Institute, Menoufiya University, Shebeen El-Kom, EgyptDepartment of Hepatology, National Liver Institute, Menoufiya University, Shebeen El-Kom, EgyptBackground/Aims. Renal impairment is a common complication of cirrhosis. Serum creatinine is less sensitive in these patients. Measurement of the glomerular filtration rate (GFR) is the gold standard but time consuming. The aim is to validate plasma NGAL (pNGAL) and urinary NGAL (uNGAL) as markers of renal function in patients with HCV related cirrhosis. Patient and Methods. One hundred HCV related end stage liver cirrhosis patients were randomized into two groups: Group I (n=35), patients with GFR < 60 mL/m measured by isotope scanning of the kidney (Renogram), and Group II (n=65), patients with GFR ≥ 60 mL/m. The pNGAL and uNGAL were measured within 2 days of the Renogram. Results. Both groups were matched with age, sex, and Child Pugh score. There was statistically significant difference between both groups regarding serum creatinine (1.98 ± 1.04 versus 1.38 ± 0.88 mg/dL; p=0.003) and pNGAL level (5.79 ± 2.06 versus 7.25 ± 3.30 ng/dL; p=0.019). Both groups were comparable (p>0.05) for the uNGAL (6.00 ± 0.78 versus 6.03 ± 0.96 ng/mL). Unlike uNGAL, the pNGAL positively correlated with total GFR by Renogram (r=0.3; p=0.001). With a cutoff ≥4 ng/mL, pNGAL had 94.3% sensitivity and 1.5% specificity and PPV = 34, NPV = 33.3, LR+ = −175.1, and LR− = −60.6. Conclusion. The pNGAL is a promising marker of the renal function in patients with cirrhosis.http://dx.doi.org/10.1155/2015/815484 |
| spellingShingle | Omkolsoum Mohamed Alhaddad Ayman Alsebaey Mohamed Omar Amer Hala Hany El-Said Tary Abdel Hamid Salman Neutrophil Gelatinase-Associated Lipocalin: A New Marker of Renal Function in C-Related End Stage Liver Disease Gastroenterology Research and Practice |
| title | Neutrophil Gelatinase-Associated Lipocalin: A New Marker of Renal Function in C-Related End Stage Liver Disease |
| title_full | Neutrophil Gelatinase-Associated Lipocalin: A New Marker of Renal Function in C-Related End Stage Liver Disease |
| title_fullStr | Neutrophil Gelatinase-Associated Lipocalin: A New Marker of Renal Function in C-Related End Stage Liver Disease |
| title_full_unstemmed | Neutrophil Gelatinase-Associated Lipocalin: A New Marker of Renal Function in C-Related End Stage Liver Disease |
| title_short | Neutrophil Gelatinase-Associated Lipocalin: A New Marker of Renal Function in C-Related End Stage Liver Disease |
| title_sort | neutrophil gelatinase associated lipocalin a new marker of renal function in c related end stage liver disease |
| url | http://dx.doi.org/10.1155/2015/815484 |
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