Fatal Cholestatic Hepatitis in an Infant: An Unusual Etiology
An infant girl who presented with cholestasis and hepatitis that rapidly progressed to fulminant liver failure is reported. Postmortem examination yielded a diagnosis of demonstrated extensive hepatic necrosis due to adenovirus type 5 infection which had developed in the setting of an occult primary...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1995-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1995/649852 |
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| _version_ | 1832563954583339008 |
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| author | Mark R Oliver Alfredo Pinto R Brent Scott |
| author_facet | Mark R Oliver Alfredo Pinto R Brent Scott |
| author_sort | Mark R Oliver |
| collection | DOAJ |
| description | An infant girl who presented with cholestasis and hepatitis that rapidly progressed to fulminant liver failure is reported. Postmortem examination yielded a diagnosis of demonstrated extensive hepatic necrosis due to adenovirus type 5 infection which had developed in the setting of an occult primary immunodeficiency (severe combined immunodeficiency). The aim of this report is to alert the physician to a rare cause of cholestasis and hepatitis in infancy. Recognition of the combination of adenoviral infection with underlying primary immunodeficiency is a prerequisite to the provision of genetic counselling. |
| format | Article |
| id | doaj-art-f7d8c691579048dba75535276798f8ed |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-f7d8c691579048dba75535276798f8ed2025-02-03T01:12:12ZengWileyCanadian Journal of Gastroenterology0835-79001995-01-019421722010.1155/1995/649852Fatal Cholestatic Hepatitis in an Infant: An Unusual EtiologyMark R Oliver0Alfredo Pinto1R Brent Scott2Department of Pediatrics and Pathology, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, CanadaDepartment of Pediatrics and Pathology, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, CanadaDepartment of Pediatrics and Pathology, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, CanadaAn infant girl who presented with cholestasis and hepatitis that rapidly progressed to fulminant liver failure is reported. Postmortem examination yielded a diagnosis of demonstrated extensive hepatic necrosis due to adenovirus type 5 infection which had developed in the setting of an occult primary immunodeficiency (severe combined immunodeficiency). The aim of this report is to alert the physician to a rare cause of cholestasis and hepatitis in infancy. Recognition of the combination of adenoviral infection with underlying primary immunodeficiency is a prerequisite to the provision of genetic counselling.http://dx.doi.org/10.1155/1995/649852 |
| spellingShingle | Mark R Oliver Alfredo Pinto R Brent Scott Fatal Cholestatic Hepatitis in an Infant: An Unusual Etiology Canadian Journal of Gastroenterology |
| title | Fatal Cholestatic Hepatitis in an Infant: An Unusual Etiology |
| title_full | Fatal Cholestatic Hepatitis in an Infant: An Unusual Etiology |
| title_fullStr | Fatal Cholestatic Hepatitis in an Infant: An Unusual Etiology |
| title_full_unstemmed | Fatal Cholestatic Hepatitis in an Infant: An Unusual Etiology |
| title_short | Fatal Cholestatic Hepatitis in an Infant: An Unusual Etiology |
| title_sort | fatal cholestatic hepatitis in an infant an unusual etiology |
| url | http://dx.doi.org/10.1155/1995/649852 |
| work_keys_str_mv | AT markroliver fatalcholestatichepatitisinaninfantanunusualetiology AT alfredopinto fatalcholestatichepatitisinaninfantanunusualetiology AT rbrentscott fatalcholestatichepatitisinaninfantanunusualetiology |