Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C
High levels of profibrinogenic cytokine transforming factor beta (TGF-β), metalloprotease (MMP2), and tissue inhibitor of matrix metalloprotease 1 (TIMP1) contribute to fibrogenesis in hepatitis C virus (HCV) infection and in alcohol-induced liver disease (ALD). The aim of our study was to correlate...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/231210 |
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| author | Manuela G. Neuman Hemda Schmilovitz-Weiss Nir Hilzenrat Marc Bourliere Patrick Marcellin Cristhian Trepo Tony Mazulli George Moussa Ankit Patel Asad A. Baig Lawrence Cohen |
| author_facet | Manuela G. Neuman Hemda Schmilovitz-Weiss Nir Hilzenrat Marc Bourliere Patrick Marcellin Cristhian Trepo Tony Mazulli George Moussa Ankit Patel Asad A. Baig Lawrence Cohen |
| author_sort | Manuela G. Neuman |
| collection | DOAJ |
| description | High levels of profibrinogenic cytokine transforming factor beta (TGF-β), metalloprotease (MMP2), and tissue inhibitor of matrix metalloprotease 1 (TIMP1) contribute to fibrogenesis in hepatitis C virus (HCV) infection and in alcohol-induced liver disease (ALD). The aim of our study was to correlate noninvasive serum markers in ALD and HCV patients with various degrees of inflammation and fibrosis in their biopsies. Methods. Serum cytokines levels in HCV-infected individuals in the presence or absence of ALD were measured. Student's-t-test with Bonferroni correction determined the significance between the groups. Results. Both tumor-necrosis-factor- (TNF)-α and TGF-β levels increased significantly with the severity of inflammation and fibrosis. TGF-β levels increased significantly in ALD patients versus the HCV patients. Proinflammatory cytokines’ responses to viral and/or toxic injury differed with the severity of liver inflammation. A combination of these markers was useful in predicting and diagnosing the stages of inflammation and fibrosis in HCV and ALD. Conclusion. Therapeutic monitoring of TGF-β and metalloproteases provides important insights into fibrosis. |
| format | Article |
| id | doaj-art-f7d89649ebb940a29853bcd21acf9e26 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-f7d89649ebb940a29853bcd21acf9e262025-02-03T07:23:32ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/231210231210Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis CManuela G. Neuman0Hemda Schmilovitz-Weiss1Nir Hilzenrat2Marc Bourliere3Patrick Marcellin4Cristhian Trepo5Tony Mazulli6George Moussa7Ankit Patel8Asad A. Baig9Lawrence Cohen10In Vitro Drug Safety and Biotechnology, MaRS Discovery Centre, 101 College Street, South Tower, Toronto, ON, M5G 1L7, CanadaGastroenterology Unit, Gastroenterology Division, Rabin Medical Center, Hasharon-Golda Campus, 7 Keren Kayemet St., Petach-Tiqwa 49372, IsraelDivision of Gastroenterology, Department of Medicine, Hepatitis SMBD—Jewish General Hospital Montreal, McGill University School of Medicine, 3755 Chemin de la Cote-St-Catherine, Montreal, QC, H3T 1E2, CanadaDepartment of Hepato-Gastroenterology, Saint-Joseph Hospital, Marseille, FranceService Hepato-Gastroenterology, Hopital Beaujon, Clichy, FranceHopital de la Croix Rousse, 103, Grande Rue de la Croix-Rousse, 69317, Lyon Cedex 04, FranceDepartment of Microbiology, Mount Sinai Hospital and Department of Laboratory Medicine, University of Toronto, 550 University Av., Toronto, ON, M5G 1L7, CanadaDepartment of Microbiology, Mount Sinai Hospital and Department of Laboratory Medicine, University of Toronto, 550 University Av., Toronto, ON, M5G 1L7, CanadaIn Vitro Drug Safety and Biotechnology, MaRS Discovery Centre, 101 College Street, South Tower, Toronto, ON, M5G 1L7, CanadaIn Vitro Drug Safety and Biotechnology, MaRS Discovery Centre, 101 College Street, South Tower, Toronto, ON, M5G 1L7, CanadaDivision of Gastroenterology, Sunnybrook Health Sciences Centre, Department of Medicine, University of Toronto, 2075 Bayview Ave, Toronto, ON, M4N 3M5, M4N 3M5, CanadaHigh levels of profibrinogenic cytokine transforming factor beta (TGF-β), metalloprotease (MMP2), and tissue inhibitor of matrix metalloprotease 1 (TIMP1) contribute to fibrogenesis in hepatitis C virus (HCV) infection and in alcohol-induced liver disease (ALD). The aim of our study was to correlate noninvasive serum markers in ALD and HCV patients with various degrees of inflammation and fibrosis in their biopsies. Methods. Serum cytokines levels in HCV-infected individuals in the presence or absence of ALD were measured. Student's-t-test with Bonferroni correction determined the significance between the groups. Results. Both tumor-necrosis-factor- (TNF)-α and TGF-β levels increased significantly with the severity of inflammation and fibrosis. TGF-β levels increased significantly in ALD patients versus the HCV patients. Proinflammatory cytokines’ responses to viral and/or toxic injury differed with the severity of liver inflammation. A combination of these markers was useful in predicting and diagnosing the stages of inflammation and fibrosis in HCV and ALD. Conclusion. Therapeutic monitoring of TGF-β and metalloproteases provides important insights into fibrosis.http://dx.doi.org/10.1155/2012/231210 |
| spellingShingle | Manuela G. Neuman Hemda Schmilovitz-Weiss Nir Hilzenrat Marc Bourliere Patrick Marcellin Cristhian Trepo Tony Mazulli George Moussa Ankit Patel Asad A. Baig Lawrence Cohen Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C International Journal of Hepatology |
| title | Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C |
| title_full | Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C |
| title_fullStr | Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C |
| title_full_unstemmed | Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C |
| title_short | Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C |
| title_sort | markers of inflammation and fibrosis in alcoholic hepatitis and viral hepatitis c |
| url | http://dx.doi.org/10.1155/2012/231210 |
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