Exercise ameliorates hepatic lipid accumulation via upregulating serum PRL and activating hepatic PRLR-mediated JAK2/STAT5 signaling pathway in NAFLD mice

Exercise ameliorates hepatic lipid accumulation via upregulating serum PRL and activating hepatic PRLR-mediated JAK2/STAT5 signaling pathway in NAFLD mice

ObjectiveNon alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, closely related to overnutrition, obesity, and metabolic syndrome. This study used exercise intervention on NAFLD mice to investigate the effect of aerobic exercise on NAFLD.MethodAfter one week of a...

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Bibliographic Details
Main Authors: Jia Fan, Kaidi Nie, Xiaobing Liu, Jiao Liu, Binghua Shao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
non-alcoholic fatty liver disease (NAFLD)
exercise
hepatic lipid accumulation
serum PRL
JAK/Stat5
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1647231/full
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