Genomic analysis of DS-1-like human rotavirus A strains uncovers genetic relatedness of NSP4 gene with animal strains in Manhiça District, Southern Mozambique

Genomic analysis of DS-1-like human rotavirus A strains uncovers genetic relatedness of NSP4 gene with animal strains in Manhiça District, Southern Mozambique

Abstract Post rotavirus vaccine introduction in Mozambique (September 2015), we documented a decline in rotavirus-associated diarrhoea and genotypes changes in our diarrhoeal surveillance spanning 2008–2021. This study aimed to perform whole-genome sequencing of rotavirus strains from 2009 to 2012 (...

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Main Authors: Filomena Manjate, Eva D. João, Peter Mwangi, Percina Chirinda, Milton Mogotsi, Marcelino Garrine, Augusto Messa, Delfino Vubil, Nélio Nobela, Karen Kotloff, James P. Nataro, Tacilta Nhampossa, Sozinho Acácio, Goitom Weldegebriel, Jacqueline E. Tate, Umesh Parashar, Jason M. Mwenda, Pedro L. Alonso, Celso Cunha, Martin Nyaga, Inácio Mandomando
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Rotavirus group A
Whole genome sequencing
Children with diarrhoea
Children without diarrhoea
Manhiça district
Mozambique
Online Access:https://doi.org/10.1038/s41598-024-79767-4
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