Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & Otto
<b>Background/Objectives:</b> <i>Argemone platyceras</i> Link & Otto, an endemic plant of Mexico, is widely distributed in the central area of the country, mainly in the states of Tlaxcala, Puebla, and the State of Mexico. Ethnobotanical studies in different communities o...
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| author | Mayra Beatriz Gómez-Patiño Rosa Estrada-Reyes Héctor Hugo Hernández-Mendoza Ángela Suarez-Rojas Daniel Arrieta-Baez |
| author_facet | Mayra Beatriz Gómez-Patiño Rosa Estrada-Reyes Héctor Hugo Hernández-Mendoza Ángela Suarez-Rojas Daniel Arrieta-Baez |
| author_sort | Mayra Beatriz Gómez-Patiño |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> <i>Argemone platyceras</i> Link & Otto, an endemic plant of Mexico, is widely distributed in the central area of the country, mainly in the states of Tlaxcala, Puebla, and the State of Mexico. Ethnobotanical studies in different communities of these states have demonstrated that it is primarily used to treat diabetes and mental illnesses, such as “los nervios” (nerves) and “el ansia” (anxiety); these terms are used in traditional medicine, but it is accepted that they refer to anxiety disorders. This study aimed to validate the traditional use of aerial parts of <i>A. platyceras</i> Link & Otto in treating these illnesses. <b>Methods:</b> a standardized acidic method to obtain alkaloids was used to obtain an extract (AlkExt), which was tested in adult male Swiss Webster mice in the tail suspension (TST) and forced swimming (FST) tests. <b>Results:</b> AlkExt was analyzed using mass spectrometry techniques (DI-ESI and UHPLC-MS) to detect 2,3′,4,5′-Tetramethoxystilbene (<i>m</i>/<i>z</i> 301.14, 3%), scoulerine (<i>m</i>/<i>z</i> 328.16, 19.8%), tetrahydro-columbamine (<i>m</i>/<i>z</i> 342.17, 28.8%), 8-(hydroxymethyl)-2,10-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-1,11-diol (<i>m</i>/<i>z</i> 358.17, 22.8%), and glaucine (<i>m</i>/<i>z</i> 356.19, 11.1%); these were assayed in a single oral administration of AlkExt, which caused robust anxiolytic- and antidepressant-like effects without affecting the spontaneous ambulatory activity of the mice. <b>Conclusions:</b> The easy and standardized AlkExt analyzed in pharmaceuticals assays in this study strongly suggest its therapeutic potential to treat the comorbidity of anxiety and depression disorders and support further investigations in people with these diseases. |
| format | Article |
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| spelling | doaj-art-f7bb4ac055ff4a879b8104cd5391e38f2025-01-24T13:45:10ZengMDPI AGPharmaceuticals1424-82472025-01-011814910.3390/ph18010049Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & OttoMayra Beatriz Gómez-Patiño0Rosa Estrada-Reyes1Héctor Hugo Hernández-Mendoza2Ángela Suarez-Rojas3Daniel Arrieta-Baez4Instituto Politécnico Nacional, Centro de Nanociencias y Micro y Nanotecnologías, Unidad Profesional Adolfo López Mateos, Av. Luis Enrique Erro S/N, Colonia Zacatenco, Mexico City 07738, MexicoLaboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Mexico City 14370, MexicoLaboratorio de Productos Naturales y Síntesis Orgánica, Facultad de Ciencias Básicas, Ingeniería y Tecnología, Universidad Autónoma de Tlaxcala, Calzada de Apizaquito S/N, San Luis Apizaquito, Tlaxcala, Apizaco 90401, MexicoLaboratorio de Productos Naturales y Síntesis Orgánica, Facultad de Ciencias Básicas, Ingeniería y Tecnología, Universidad Autónoma de Tlaxcala, Calzada de Apizaquito S/N, San Luis Apizaquito, Tlaxcala, Apizaco 90401, MexicoInstituto Politécnico Nacional, Centro de Nanociencias y Micro y Nanotecnologías, Unidad Profesional Adolfo López Mateos, Av. Luis Enrique Erro S/N, Colonia Zacatenco, Mexico City 07738, Mexico<b>Background/Objectives:</b> <i>Argemone platyceras</i> Link & Otto, an endemic plant of Mexico, is widely distributed in the central area of the country, mainly in the states of Tlaxcala, Puebla, and the State of Mexico. Ethnobotanical studies in different communities of these states have demonstrated that it is primarily used to treat diabetes and mental illnesses, such as “los nervios” (nerves) and “el ansia” (anxiety); these terms are used in traditional medicine, but it is accepted that they refer to anxiety disorders. This study aimed to validate the traditional use of aerial parts of <i>A. platyceras</i> Link & Otto in treating these illnesses. <b>Methods:</b> a standardized acidic method to obtain alkaloids was used to obtain an extract (AlkExt), which was tested in adult male Swiss Webster mice in the tail suspension (TST) and forced swimming (FST) tests. <b>Results:</b> AlkExt was analyzed using mass spectrometry techniques (DI-ESI and UHPLC-MS) to detect 2,3′,4,5′-Tetramethoxystilbene (<i>m</i>/<i>z</i> 301.14, 3%), scoulerine (<i>m</i>/<i>z</i> 328.16, 19.8%), tetrahydro-columbamine (<i>m</i>/<i>z</i> 342.17, 28.8%), 8-(hydroxymethyl)-2,10-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-1,11-diol (<i>m</i>/<i>z</i> 358.17, 22.8%), and glaucine (<i>m</i>/<i>z</i> 356.19, 11.1%); these were assayed in a single oral administration of AlkExt, which caused robust anxiolytic- and antidepressant-like effects without affecting the spontaneous ambulatory activity of the mice. <b>Conclusions:</b> The easy and standardized AlkExt analyzed in pharmaceuticals assays in this study strongly suggest its therapeutic potential to treat the comorbidity of anxiety and depression disorders and support further investigations in people with these diseases.https://www.mdpi.com/1424-8247/18/1/49<i>Argemone platyceras</i>antidepressant effectanxiolytic effectdirect infusion electro-spray (DIESI)UHPLC-MS |
| spellingShingle | Mayra Beatriz Gómez-Patiño Rosa Estrada-Reyes Héctor Hugo Hernández-Mendoza Ángela Suarez-Rojas Daniel Arrieta-Baez Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & Otto Pharmaceuticals <i>Argemone platyceras</i> antidepressant effect anxiolytic effect direct infusion electro-spray (DIESI) UHPLC-MS |
| title | Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & Otto |
| title_full | Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & Otto |
| title_fullStr | Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & Otto |
| title_full_unstemmed | Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & Otto |
| title_short | Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & Otto |
| title_sort | antidepressant and anxiolytic like effects in mice of alkaloids from aerial parts of i argemone platyceras i link otto |
| topic | <i>Argemone platyceras</i> antidepressant effect anxiolytic effect direct infusion electro-spray (DIESI) UHPLC-MS |
| url | https://www.mdpi.com/1424-8247/18/1/49 |
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