In situ delivery of synthetic preimplantation factor using aldehyde-modified hyaluronic acid hydrogel with immobilized complexes of chondroitin sulfate derivatives

In situ delivery of synthetic preimplantation factor using aldehyde-modified hyaluronic acid hydrogel with immobilized complexes of chondroitin sulfate derivatives

Synthetic preimplantation factor (SPIF) is a promising therapeutic agent for chronic inflammatory diseases like Multiple Sclerosis (MS), but frequent systemic dosing limits patient adherence and therapy efficacy. This study presents an injectable drug delivery system (DDS) using 2 % (w/v) aldehyde-m...

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Bibliographic Details
Main Authors: Tutut Habibah, Andrea Exnerová, Kristina Nešporová, Una FitzGerald, Abhay Pandit, Marek Ingr, Martin Pravda, Vladimír Velebný
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Carbohydrate Polymer Technologies and Applications
Subjects:
Hydrogel
Synthetic preimplantation factor
Hyaluronic acid, Chondroitin sulfate
Polyelectrolyte complexes
Online Access:http://www.sciencedirect.com/science/article/pii/S2666893925000283
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