Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease
Genes important for mitochondrial function have been implicated in Parkinson's disease (PD). Mitochondrial translation initiation factor 3 (MTIF3) is a nuclear encoded protein required for the initiation of complex formation on mitochondrial ribosomes. Dysfunction of MTIF3 may impair mitochondr...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.4061/2010/491751 |
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| _version_ | 1832558216067678208 |
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| author | Anna Anvret Caroline Ran Marie Westerlund Ann-Christin Thelander Olof Sydow Charlotta Lind Anna Håkansson Hans Nissbrandt Dagmar Galter Andrea Carmine Belin |
| author_facet | Anna Anvret Caroline Ran Marie Westerlund Ann-Christin Thelander Olof Sydow Charlotta Lind Anna Håkansson Hans Nissbrandt Dagmar Galter Andrea Carmine Belin |
| author_sort | Anna Anvret |
| collection | DOAJ |
| description | Genes important for mitochondrial function have been implicated in Parkinson's disease (PD). Mitochondrial translation initiation factor 3 (MTIF3) is a nuclear encoded protein required for the initiation of complex formation on mitochondrial ribosomes. Dysfunction of MTIF3 may impair mitochondrial function and dopamine neurons appear to be particularly vulnerable to oxidative stress, which may relate to their degeneration in PD. An association was recently reported between the synonymous rs7669(C>T) in MTIF3 and PD in a German case-control material. We investigated rs7669 in a Swedish Parkinson case-control material. The study revealed no significant association of the individual genotypes or alleles with PD. When comparing the combined TT/CT-genotypes versus the CC-genotype, we observed a significant association (P=.0473) with PD. We also demonstrated that the TT-genotype causes a significant decrease in MTIF3 mRNA expression compared to the CC-genotype (P=.0163). Our findings support the hypothesis that MTIF3 may be involved in the etiology of PD. |
| format | Article |
| id | doaj-art-f79728a3ff9245f7aaf5035c75c3e2bc |
| institution | Kabale University |
| issn | 2042-0080 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-f79728a3ff9245f7aaf5035c75c3e2bc2025-02-03T01:33:04ZengWileyParkinson's Disease2042-00802010-01-01201010.4061/2010/491751491751Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's DiseaseAnna Anvret0Caroline Ran1Marie Westerlund2Ann-Christin Thelander3Olof Sydow4Charlotta Lind5Anna Håkansson6Hans Nissbrandt7Dagmar Galter8Andrea Carmine Belin9Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, SwedenDepartment of Neuroscience, Karolinska Institutet, 171 77 Stockholm, SwedenDepartment of Neuroscience, Karolinska Institutet, 171 77 Stockholm, SwedenNeurology Section, Department of Clinical Neuroscience, Karolinska University Hospital, 171 76 Stockholm, SwedenNeurology Section, Department of Clinical Neuroscience, Karolinska University Hospital, 171 76 Stockholm, SwedenNeurology Section, Department of Clinical Neuroscience, Karolinska University Hospital, 171 76 Stockholm, SwedenDepartment of Pharmacology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, SwedenDepartment of Pharmacology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, SwedenDepartment of Neuroscience, Karolinska Institutet, 171 77 Stockholm, SwedenDepartment of Neuroscience, Karolinska Institutet, 171 77 Stockholm, SwedenGenes important for mitochondrial function have been implicated in Parkinson's disease (PD). Mitochondrial translation initiation factor 3 (MTIF3) is a nuclear encoded protein required for the initiation of complex formation on mitochondrial ribosomes. Dysfunction of MTIF3 may impair mitochondrial function and dopamine neurons appear to be particularly vulnerable to oxidative stress, which may relate to their degeneration in PD. An association was recently reported between the synonymous rs7669(C>T) in MTIF3 and PD in a German case-control material. We investigated rs7669 in a Swedish Parkinson case-control material. The study revealed no significant association of the individual genotypes or alleles with PD. When comparing the combined TT/CT-genotypes versus the CC-genotype, we observed a significant association (P=.0473) with PD. We also demonstrated that the TT-genotype causes a significant decrease in MTIF3 mRNA expression compared to the CC-genotype (P=.0163). Our findings support the hypothesis that MTIF3 may be involved in the etiology of PD.http://dx.doi.org/10.4061/2010/491751 |
| spellingShingle | Anna Anvret Caroline Ran Marie Westerlund Ann-Christin Thelander Olof Sydow Charlotta Lind Anna Håkansson Hans Nissbrandt Dagmar Galter Andrea Carmine Belin Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease Parkinson's Disease |
| title | Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease |
| title_full | Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease |
| title_fullStr | Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease |
| title_full_unstemmed | Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease |
| title_short | Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease |
| title_sort | possible involvement of a mitochondrial translation initiation factor 3 variant causing decreased mrna levels in parkinson s disease |
| url | http://dx.doi.org/10.4061/2010/491751 |
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