Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer
Introduction. Cyclooxygenase-2 (COX-2) expression is elevated in colorectal cancer (CRC). However, data about the relation between COX-2 expression and the impact on the biologic behavior of recurrent disease are inconclusive as yet. The aim of this study is to investigate the relationship between t...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/7968149 |
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| author | Sung Hoo Kim Byung Kyu Ahn Seung Sam Paik Kang Hong Lee |
| author_facet | Sung Hoo Kim Byung Kyu Ahn Seung Sam Paik Kang Hong Lee |
| author_sort | Sung Hoo Kim |
| collection | DOAJ |
| description | Introduction. Cyclooxygenase-2 (COX-2) expression is elevated in colorectal cancer (CRC). However, data about the relation between COX-2 expression and the impact on the biologic behavior of recurrent disease are inconclusive as yet. The aim of this study is to investigate the relationship between the status of COX-2 expression in the primary CRC and the characteristics of recurrence after curative resection of stage I to III CRC. Materials and Methods. Ninety-eight patients with recurrence in 376 CRC patients, who underwent curative surgery between January 1991 and August 2001, were retrospectively assessed. Immunohistochemical staining, performed for the presence of COX-2 on tissue microarrays, was analyzed. Results. Forty-six patients showed elevated COX-2 expression, and 52 patients did not. The mean time to recurrence was significantly longer in the positive group than in the negative group (34.1 months ± 30.0 versus 21.9 months ± 17.4; P=0.019). Positive COX-2 expression was correlated with late recurrence (>3 years after surgery) [43.5% versus 13.5%; P=0.001]. In multivariate analysis, COX-2 expression was an independent factor associated with late recurrence (OR 4.656; 95% CI, 1.696 to 12.779; P=0.003). Recurrence pattern and postrecurrence survival were not different between the two groups. Conclusions. Elevated COX-2 expression in itself is not a prognostic factor, but COX-2 expression in tumor tissue may be an independent predictive marker of late recurrence for patients with stage I to III CRC. |
| format | Article |
| id | doaj-art-f790695f048647e4991d919061d8e126 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-f790695f048647e4991d919061d8e1262025-02-03T05:46:56ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/79681497968149Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal CancerSung Hoo Kim0Byung Kyu Ahn1Seung Sam Paik2Kang Hong Lee3Department of Surgery, Hanyang University College of Medicine, Seoul, Republic of KoreaDepartment of Surgery, Hanyang University College of Medicine, Seoul, Republic of KoreaDepartment of Pathology, Hanyang University College of Medicine, Seoul, Republic of KoreaDepartment of Surgery, Hanyang University College of Medicine, Seoul, Republic of KoreaIntroduction. Cyclooxygenase-2 (COX-2) expression is elevated in colorectal cancer (CRC). However, data about the relation between COX-2 expression and the impact on the biologic behavior of recurrent disease are inconclusive as yet. The aim of this study is to investigate the relationship between the status of COX-2 expression in the primary CRC and the characteristics of recurrence after curative resection of stage I to III CRC. Materials and Methods. Ninety-eight patients with recurrence in 376 CRC patients, who underwent curative surgery between January 1991 and August 2001, were retrospectively assessed. Immunohistochemical staining, performed for the presence of COX-2 on tissue microarrays, was analyzed. Results. Forty-six patients showed elevated COX-2 expression, and 52 patients did not. The mean time to recurrence was significantly longer in the positive group than in the negative group (34.1 months ± 30.0 versus 21.9 months ± 17.4; P=0.019). Positive COX-2 expression was correlated with late recurrence (>3 years after surgery) [43.5% versus 13.5%; P=0.001]. In multivariate analysis, COX-2 expression was an independent factor associated with late recurrence (OR 4.656; 95% CI, 1.696 to 12.779; P=0.003). Recurrence pattern and postrecurrence survival were not different between the two groups. Conclusions. Elevated COX-2 expression in itself is not a prognostic factor, but COX-2 expression in tumor tissue may be an independent predictive marker of late recurrence for patients with stage I to III CRC.http://dx.doi.org/10.1155/2018/7968149 |
| spellingShingle | Sung Hoo Kim Byung Kyu Ahn Seung Sam Paik Kang Hong Lee Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer Gastroenterology Research and Practice |
| title | Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer |
| title_full | Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer |
| title_fullStr | Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer |
| title_full_unstemmed | Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer |
| title_short | Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer |
| title_sort | cyclooxygenase 2 expression is a predictive marker for late recurrence in colorectal cancer |
| url | http://dx.doi.org/10.1155/2018/7968149 |
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