Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromsø OGTT Study
HbA1c 6.5% has recently been recommended as an alternative diagnostic criterion for diabetes. The aims of the study were to evaluate the effects of age, sex, and other factors on prevalence of diabetes and to compare risk profiles of subjects with diabetes when defined by HbA1c and glucose criteria....
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/613475 |
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| author | Moira Strand Hutchinson Ragnar Martin Joakimsen Inger Njølstad Henrik Schirmer Yngve Figenschau Johan Svartberg Rolf Jorde |
| author_facet | Moira Strand Hutchinson Ragnar Martin Joakimsen Inger Njølstad Henrik Schirmer Yngve Figenschau Johan Svartberg Rolf Jorde |
| author_sort | Moira Strand Hutchinson |
| collection | DOAJ |
| description | HbA1c 6.5% has recently been recommended as an alternative diagnostic criterion for diabetes. The aims of the study were to evaluate the effects of age, sex, and other factors on prevalence of diabetes and to compare risk profiles of subjects with diabetes when defined by HbA1c and glucose criteria. Subjects were recruited among participants in the longitudinal population-based Tromsø Study. HbA1c, fasting plasma glucose, and 2-hour plasma glucose were measured in 3,476 subjects. In total, 294 subjects met one or more of the diagnostic criteria for diabetes; 95 met the HbA1c criterion only, 130 met the glucose criteria only, and 69 met both. Among subjects with diabetes detected by glucose criteria (regardless of HbA1c), isolated raised 2-hour plasma glucose was more common in subjects aged ≥ 60 years as compared to younger subjects and in elderly women as compared to elderly men. Subjects with diabetes detected by glucose criteria only had worse cardiometabolic risk profiles than those detected by HbA1c only. In conclusion, the current HbA1c and glucose criteria defined different subjects with diabetes with only modest overlap. Among a substantial proportion of elderly subjects, and especially elderly women, the 2-hour plasma glucose was the only abnormal value. |
| format | Article |
| id | doaj-art-f78afdf2996f427f943edaf30a56528f |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f78afdf2996f427f943edaf30a56528f2025-02-03T06:14:08ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/613475613475Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromsø OGTT StudyMoira Strand Hutchinson0Ragnar Martin Joakimsen1Inger Njølstad2Henrik Schirmer3Yngve Figenschau4Johan Svartberg5Rolf Jorde6Tromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, NorwayTromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, NorwayDepartment of Community Medicine, University of Tromsø, 9037 Tromsø, NorwayDivision of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, NorwayTromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, NorwayTromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, NorwayTromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, NorwayHbA1c 6.5% has recently been recommended as an alternative diagnostic criterion for diabetes. The aims of the study were to evaluate the effects of age, sex, and other factors on prevalence of diabetes and to compare risk profiles of subjects with diabetes when defined by HbA1c and glucose criteria. Subjects were recruited among participants in the longitudinal population-based Tromsø Study. HbA1c, fasting plasma glucose, and 2-hour plasma glucose were measured in 3,476 subjects. In total, 294 subjects met one or more of the diagnostic criteria for diabetes; 95 met the HbA1c criterion only, 130 met the glucose criteria only, and 69 met both. Among subjects with diabetes detected by glucose criteria (regardless of HbA1c), isolated raised 2-hour plasma glucose was more common in subjects aged ≥ 60 years as compared to younger subjects and in elderly women as compared to elderly men. Subjects with diabetes detected by glucose criteria only had worse cardiometabolic risk profiles than those detected by HbA1c only. In conclusion, the current HbA1c and glucose criteria defined different subjects with diabetes with only modest overlap. Among a substantial proportion of elderly subjects, and especially elderly women, the 2-hour plasma glucose was the only abnormal value.http://dx.doi.org/10.1155/2013/613475 |
| spellingShingle | Moira Strand Hutchinson Ragnar Martin Joakimsen Inger Njølstad Henrik Schirmer Yngve Figenschau Johan Svartberg Rolf Jorde Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromsø OGTT Study International Journal of Endocrinology |
| title | Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromsø OGTT Study |
| title_full | Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromsø OGTT Study |
| title_fullStr | Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromsø OGTT Study |
| title_full_unstemmed | Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromsø OGTT Study |
| title_short | Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromsø OGTT Study |
| title_sort | effects of age and sex on estimated diabetes prevalence using different diagnostic criteria the tromso ogtt study |
| url | http://dx.doi.org/10.1155/2013/613475 |
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