Catechol-based chemistry for hypoglycemia-responsive delivery of zinc-glucagon via hydrogel-based microneedle patch technology

Abstract Hypoglycemia is a serious and potentially life-threatening condition for people with insulin-dependent diabetes. To provide a safeguard against hypoglycemia, we introduce a “smart” microneedle (MN) patch that senses glucose levels and delivers a blood glucose-raising agent (Zinc-Glucagon (Z...

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Bibliographic Details
Main Authors: Amin GhavamiNejad, Jackie Fule Liu, Sako Mirzaie, Brian Lu, Melisa Samarikhalaj, Adria Giacca, Xiao Yu Wu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58278-4
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