Serotoninergic modulation in the brainstem and hypothalamus of female overnourished rats: impact on mitochondrial markers, oxidative stress and BDNF mRNA levels

Serotoninergic modulation in the brainstem and hypothalamus of female overnourished rats: impact on mitochondrial markers, oxidative stress and BDNF mRNA levels

IntroductionObesity is a global epidemic identified by the World Health Organization, and its complexity involves genetic, cultural, socioeconomic, and behavioral factors.MethodsIn this study, we used female Wistar rats, with litters standardized to nine female pups, which were divided into two grou...

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Main Authors: Thyago de Oliveira Rodrigues, Osmar Henrique dos Santos Júnior, Maria Daniele Teixeira Beltrão de Lemos, Matheus Santos de Sousa Fernandes, Fatma Hilal Yagin, Burak Yagin, Samarjit Das, Abdullah F. Alghannam, Pablo Prieto-González, Claudia J. Lagranha
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
obesity
serotonin
fluoxetine
hypothalamus
overnutrition
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1564061/full
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