Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults
Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. Thus,...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/1796204 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565897514975232 |
|---|---|
| author | Wellington F. Rodrigues Camila B. Miguel Ferdinando Agostinho Gabriela V. da Silva Javier E. Lazo-Chica Sandra M. Naressi Scapin Marcelo H. Napimoga Carlos A. Trindade-da-Silva José E. Krieger Alexandre da Costa Pereira Carlo J. Freire Oliveira Siomar de Castro Soares Carlos Ueira-Vieira |
| author_facet | Wellington F. Rodrigues Camila B. Miguel Ferdinando Agostinho Gabriela V. da Silva Javier E. Lazo-Chica Sandra M. Naressi Scapin Marcelo H. Napimoga Carlos A. Trindade-da-Silva José E. Krieger Alexandre da Costa Pereira Carlo J. Freire Oliveira Siomar de Castro Soares Carlos Ueira-Vieira |
| author_sort | Wellington F. Rodrigues |
| collection | DOAJ |
| description | Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. Thus, we evaluated the inflammatory exudate present in crevicular fluid to identify metabolic biological markers for diagnosing chronic periodontal disease in older adults. Research participants were selected from long-term institutions in Brazil. Participants were individuals aged 65 years or older, healthy, or with chronic periodontal disease. Gas chromatography/mass spectrometry was used to evaluate potential biomarkers in 120 crevicular fluid samples. We identified 969 metabolites in the individuals. Of these, 15 metabolites showed a variable importance with projection score>1 and were associated with periodontal disease. Further analysis showed that among the 15 metabolites, two (5-aminovaleric acid and serine, 3TMS derivative) were found at higher concentrations in the crevicular fluid, indicating their potential diagnostic power for periodontal disease in older adults. Our findings indicated that some metabolites are present at high concentrations in the crevicular fluid in older adults with periodontal disease and can be used as biomarkers of periodontal disease. |
| format | Article |
| id | doaj-art-f775ee1e89a5411ebe329168f779e136 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f775ee1e89a5411ebe329168f779e1362025-02-03T01:06:17ZengWileyMediators of Inflammation1466-18612021-01-01202110.1155/2021/1796204Metabolomic Evaluation of Chronic Periodontal Disease in Older AdultsWellington F. Rodrigues0Camila B. Miguel1Ferdinando Agostinho2Gabriela V. da Silva3Javier E. Lazo-Chica4Sandra M. Naressi Scapin5Marcelo H. Napimoga6Carlos A. Trindade-da-Silva7José E. Krieger8Alexandre da Costa Pereira9Carlo J. Freire Oliveira10Siomar de Castro Soares11Carlos Ueira-Vieira12Postgraduate Course in Health SciencesPostgraduate Course in Health SciencesPostgraduate Course in Physiological SciencesHeart Institute-INCORCell Biology LaboratoryInstituto Nacional de MetrologiaInstitute and Research Center São Leopoldo MandicInstitute of Genetics and BiochemistryHeart Institute-INCORHeart Institute-INCORPostgraduate Course in Health SciencesPostgraduate Course in Physiological SciencesInstitute of Genetics and BiochemistryPeriodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. Thus, we evaluated the inflammatory exudate present in crevicular fluid to identify metabolic biological markers for diagnosing chronic periodontal disease in older adults. Research participants were selected from long-term institutions in Brazil. Participants were individuals aged 65 years or older, healthy, or with chronic periodontal disease. Gas chromatography/mass spectrometry was used to evaluate potential biomarkers in 120 crevicular fluid samples. We identified 969 metabolites in the individuals. Of these, 15 metabolites showed a variable importance with projection score>1 and were associated with periodontal disease. Further analysis showed that among the 15 metabolites, two (5-aminovaleric acid and serine, 3TMS derivative) were found at higher concentrations in the crevicular fluid, indicating their potential diagnostic power for periodontal disease in older adults. Our findings indicated that some metabolites are present at high concentrations in the crevicular fluid in older adults with periodontal disease and can be used as biomarkers of periodontal disease.http://dx.doi.org/10.1155/2021/1796204 |
| spellingShingle | Wellington F. Rodrigues Camila B. Miguel Ferdinando Agostinho Gabriela V. da Silva Javier E. Lazo-Chica Sandra M. Naressi Scapin Marcelo H. Napimoga Carlos A. Trindade-da-Silva José E. Krieger Alexandre da Costa Pereira Carlo J. Freire Oliveira Siomar de Castro Soares Carlos Ueira-Vieira Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults Mediators of Inflammation |
| title | Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults |
| title_full | Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults |
| title_fullStr | Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults |
| title_full_unstemmed | Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults |
| title_short | Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults |
| title_sort | metabolomic evaluation of chronic periodontal disease in older adults |
| url | http://dx.doi.org/10.1155/2021/1796204 |
| work_keys_str_mv | AT wellingtonfrodrigues metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT camilabmiguel metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT ferdinandoagostinho metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT gabrielavdasilva metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT javierelazochica metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT sandramnaressiscapin metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT marcelohnapimoga metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT carlosatrindadedasilva metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT joseekrieger metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT alexandredacostapereira metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT carlojfreireoliveira metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT siomardecastrosoares metabolomicevaluationofchronicperiodontaldiseaseinolderadults AT carlosueiravieira metabolomicevaluationofchronicperiodontaldiseaseinolderadults |