CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population
Background. Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. Our previous studies showed expression of CD40 ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD. Other studies from Japan suggested the role of CD40L in the...
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2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/520865 |
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| author | Ho-Chang Kuo Mei-Chyn Chao Yu-Wen Hsu Ying-Chi Lin Ying-Hsien Huang Hong-Ren Yu Ming-Feng Hou Chi-Di Liang Kuender D. Yang Wei-Chiao Chang Chih-Lu Wang |
| author_facet | Ho-Chang Kuo Mei-Chyn Chao Yu-Wen Hsu Ying-Chi Lin Ying-Hsien Huang Hong-Ren Yu Ming-Feng Hou Chi-Di Liang Kuender D. Yang Wei-Chiao Chang Chih-Lu Wang |
| author_sort | Ho-Chang Kuo |
| collection | DOAJ |
| description | Background. Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. Our previous studies showed expression of CD40 ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD. Other studies from Japan suggested the role of CD40L in the pathogenesis of CAL, and this might help explain the excessive number of males affected with KD but cannot be reproduced by Taiwanese population. This study was conducted to investigate the CD40 polymorphism in KD and CAL formation.
Methods. A total of 950 subjects (381 KD patients and 569 controls) were investigated to identify 2 tagging single-nucleotide polymorphisms (tSNPs) of CD40 (rs4810485 and rs1535045) by using the TaqMan allelic discrimination assay. Results. A significant association was noted with regards to CD40 tSNPs (rs1535045) between controls and KD patients (P=0.0405, dominant model). In KD patients, polymorphisms of CD40 (rs4810485) showed significant association with CAL formation (P=0.0436, recessive model). Haplotype analysis did not yield more significant results between polymorphisms of CD40 and susceptibility/disease activity of KD. Conclusions. This study showed for the first time that polymorphisms of CD40 are associated with susceptibility to KD and CAL formation, in the Taiwanese population. |
| format | Article |
| id | doaj-art-f77422780a5744d78b104e8873d27940 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-f77422780a5744d78b104e8873d279402025-02-03T01:22:15ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/520865520865CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese PopulationHo-Chang Kuo0Mei-Chyn Chao1Yu-Wen Hsu2Ying-Chi Lin3Ying-Hsien Huang4Hong-Ren Yu5Ming-Feng Hou6Chi-Di Liang7Kuender D. Yang8Wei-Chiao Chang9Chih-Lu Wang10Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanSchool of Pharmacy, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanCancer Center, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartments of Medical Research and Pediatrics, Show Chwan Memorial Hospital in Chang Bing, Changhua, TaiwanDepartment of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Pediatrics, Po-Jen Hospital, Kaohsiung, TaiwanBackground. Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. Our previous studies showed expression of CD40 ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD. Other studies from Japan suggested the role of CD40L in the pathogenesis of CAL, and this might help explain the excessive number of males affected with KD but cannot be reproduced by Taiwanese population. This study was conducted to investigate the CD40 polymorphism in KD and CAL formation. Methods. A total of 950 subjects (381 KD patients and 569 controls) were investigated to identify 2 tagging single-nucleotide polymorphisms (tSNPs) of CD40 (rs4810485 and rs1535045) by using the TaqMan allelic discrimination assay. Results. A significant association was noted with regards to CD40 tSNPs (rs1535045) between controls and KD patients (P=0.0405, dominant model). In KD patients, polymorphisms of CD40 (rs4810485) showed significant association with CAL formation (P=0.0436, recessive model). Haplotype analysis did not yield more significant results between polymorphisms of CD40 and susceptibility/disease activity of KD. Conclusions. This study showed for the first time that polymorphisms of CD40 are associated with susceptibility to KD and CAL formation, in the Taiwanese population.http://dx.doi.org/10.1100/2012/520865 |
| spellingShingle | Ho-Chang Kuo Mei-Chyn Chao Yu-Wen Hsu Ying-Chi Lin Ying-Hsien Huang Hong-Ren Yu Ming-Feng Hou Chi-Di Liang Kuender D. Yang Wei-Chiao Chang Chih-Lu Wang CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population The Scientific World Journal |
| title | CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population |
| title_full | CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population |
| title_fullStr | CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population |
| title_full_unstemmed | CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population |
| title_short | CD40 Gene Polymorphisms Associated with Susceptibility and Coronary Artery Lesions of Kawasaki Disease in the Taiwanese Population |
| title_sort | cd40 gene polymorphisms associated with susceptibility and coronary artery lesions of kawasaki disease in the taiwanese population |
| url | http://dx.doi.org/10.1100/2012/520865 |
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