Development of technology for culturing a cell line producing a single-domain antibody fused with the Fc fragment of human IgG1

Development of technology for culturing a cell line producing a single-domain antibody fused with the Fc fragment of human IgG1

Objectives. To develop an effective technology for the cultivation of Chinese hamster ovary (CHO) cells stably producing GamP2C5 antibody which is a component I of the GamCoviMab candidate drug for emergency prevention and therapy of  infection caused by SARS-CoV-2 virus; to select optimal cultivati...

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Bibliographic Details
Main Authors: D. S. Polyansky, E. I. Ryabova, A. A. Derkaev, N. S. Starkov, I. S. Kashapova, D. V. Shcheblyakov, A. P. Karpov, I. B. Esmagambetov
Format: Article
Language:Russian
Published: MIREA - Russian Technological University 2024-07-01
Series:Тонкие химические технологии
Subjects:
monoclonal antibodies
single-domain antibodies
heavy chain antibodies
cultivation
cho cells
bioprocess scaling
Online Access:https://www.finechem-mirea.ru/jour/article/view/2088
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