Stratification of Anatomical Imaging Features Between High-Risk and Non-High-Risk Groups in Neuroblastoma
Background This study compared anatomical imaging features between high-risk and non-high-risk groups in neuroblastoma with at least one image-defined risk factor (IDRF). It also assessed the diagnostic performance of these features in identifying the high-risk group. Methods A retrospective analysi...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748251315883 |
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| author | Haoru Wang MD Xin Chen MD Ling He MD Jinhua Cai MD, PhD |
| author_facet | Haoru Wang MD Xin Chen MD Ling He MD Jinhua Cai MD, PhD |
| author_sort | Haoru Wang MD |
| collection | DOAJ |
| description | Background This study compared anatomical imaging features between high-risk and non-high-risk groups in neuroblastoma with at least one image-defined risk factor (IDRF). It also assessed the diagnostic performance of these features in identifying the high-risk group. Methods A retrospective analysis of neuroblastoma patients with at least one IDRF was conducted. Imaging features, including estimated tumor volume and IDRFs, were compared between the two groups. The diagnostic performance of these features was assessed using receiver operating characteristic (ROC) curves, and the areas under the ROC curves (AUCs) along with their 95% confidence intervals (CIs) were calculated. Additionally, to internally validate their diagnostic performance, the bootstrap resampling method with 1000 bootstrap resamples was employed. Results The study included 255 patients (185 high-risk cases, 70 non-high-risk cases). Significant differences were found in estimated tumor volume and IDRF number between the high-risk and non-high-risk groups ( P < 0.001). The estimated tumor volume and the IDRF number-based cluster were independent risk factors, and their combination achieved an AUC of 0.801 (95% CI: 0.747-0.848) for high-risk group diagnosis, with the average AUC of the 1000 bootstrap samples of 0.800 (95% CI: 0.798-0.802). In abdominal lesions, specific IDRF categories differed between high-risk and non-high-risk groups ( P < 0.05). Conclusion Our study reveals anatomical imaging differences between high-risk and non-high-risk groups in neuroblastoma with at least one IDRF. |
| format | Article |
| id | doaj-art-f77165bc2bf940f78f66635095ff0bc6 |
| institution | Kabale University |
| issn | 1526-2359 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj-art-f77165bc2bf940f78f66635095ff0bc62025-01-21T05:03:19ZengSAGE PublishingCancer Control1526-23592025-01-013210.1177/10732748251315883Stratification of Anatomical Imaging Features Between High-Risk and Non-High-Risk Groups in NeuroblastomaHaoru Wang MDXin Chen MDLing He MDJinhua Cai MD, PhDBackground This study compared anatomical imaging features between high-risk and non-high-risk groups in neuroblastoma with at least one image-defined risk factor (IDRF). It also assessed the diagnostic performance of these features in identifying the high-risk group. Methods A retrospective analysis of neuroblastoma patients with at least one IDRF was conducted. Imaging features, including estimated tumor volume and IDRFs, were compared between the two groups. The diagnostic performance of these features was assessed using receiver operating characteristic (ROC) curves, and the areas under the ROC curves (AUCs) along with their 95% confidence intervals (CIs) were calculated. Additionally, to internally validate their diagnostic performance, the bootstrap resampling method with 1000 bootstrap resamples was employed. Results The study included 255 patients (185 high-risk cases, 70 non-high-risk cases). Significant differences were found in estimated tumor volume and IDRF number between the high-risk and non-high-risk groups ( P < 0.001). The estimated tumor volume and the IDRF number-based cluster were independent risk factors, and their combination achieved an AUC of 0.801 (95% CI: 0.747-0.848) for high-risk group diagnosis, with the average AUC of the 1000 bootstrap samples of 0.800 (95% CI: 0.798-0.802). In abdominal lesions, specific IDRF categories differed between high-risk and non-high-risk groups ( P < 0.05). Conclusion Our study reveals anatomical imaging differences between high-risk and non-high-risk groups in neuroblastoma with at least one IDRF.https://doi.org/10.1177/10732748251315883 |
| spellingShingle | Haoru Wang MD Xin Chen MD Ling He MD Jinhua Cai MD, PhD Stratification of Anatomical Imaging Features Between High-Risk and Non-High-Risk Groups in Neuroblastoma Cancer Control |
| title | Stratification of Anatomical Imaging Features Between High-Risk and Non-High-Risk Groups in Neuroblastoma |
| title_full | Stratification of Anatomical Imaging Features Between High-Risk and Non-High-Risk Groups in Neuroblastoma |
| title_fullStr | Stratification of Anatomical Imaging Features Between High-Risk and Non-High-Risk Groups in Neuroblastoma |
| title_full_unstemmed | Stratification of Anatomical Imaging Features Between High-Risk and Non-High-Risk Groups in Neuroblastoma |
| title_short | Stratification of Anatomical Imaging Features Between High-Risk and Non-High-Risk Groups in Neuroblastoma |
| title_sort | stratification of anatomical imaging features between high risk and non high risk groups in neuroblastoma |
| url | https://doi.org/10.1177/10732748251315883 |
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