Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells
A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved. From the perspectives of clinicians and researche...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/4287158 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849469084177006592 |
|---|---|
| author | Aoife Gowran Marco Rasponi Roberta Visone Patrizia Nigro Gianluca L. Perrucci Stefano Righetti Marco Zanobini Giulio Pompilio |
| author_facet | Aoife Gowran Marco Rasponi Roberta Visone Patrizia Nigro Gianluca L. Perrucci Stefano Righetti Marco Zanobini Giulio Pompilio |
| author_sort | Aoife Gowran |
| collection | DOAJ |
| description | A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved. From the perspectives of clinicians and researchers alike, the promise of induced pluripotent stem cells is alluring if somewhat beguiling. It is now evident that this technology is nascent and many areas for refinement have been identified and need to be considered before induced pluripotent stem cells can be routinely used to stratify, treat and cure patients, and to faithfully model diseases for drug screening purposes. This review specifically addresses the pioneering approaches to improve induced pluripotent stem cell based models of nonischaemic cardiomyopathy. |
| format | Article |
| id | doaj-art-f76266b7664b47ff934aff0d8e2e765c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f76266b7664b47ff934aff0d8e2e765c2025-08-20T03:25:38ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/42871584287158Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem CellsAoife Gowran0Marco Rasponi1Roberta Visone2Patrizia Nigro3Gianluca L. Perrucci4Stefano Righetti5Marco Zanobini6Giulio Pompilio7Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138 Milan, ItalyDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, Building No. 21, 20133 Milan, ItalyDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, Building No. 21, 20133 Milan, ItalyUnit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138 Milan, ItalyDepartment of Clinical Sciences and Community Health, University of Milan, Via Festa del Perdono 7, 20122 Milan, ItalyCardiology Unit, San Gerardo Hospital, Via Giambattista Pergolesi 33, 20052 Monza, ItalyDepartment of Cardiac Surgery, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138 Milan, ItalyUnit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino-IRCCS, Via Parea 4, 20138 Milan, ItalyA mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved. From the perspectives of clinicians and researchers alike, the promise of induced pluripotent stem cells is alluring if somewhat beguiling. It is now evident that this technology is nascent and many areas for refinement have been identified and need to be considered before induced pluripotent stem cells can be routinely used to stratify, treat and cure patients, and to faithfully model diseases for drug screening purposes. This review specifically addresses the pioneering approaches to improve induced pluripotent stem cell based models of nonischaemic cardiomyopathy.http://dx.doi.org/10.1155/2016/4287158 |
| spellingShingle | Aoife Gowran Marco Rasponi Roberta Visone Patrizia Nigro Gianluca L. Perrucci Stefano Righetti Marco Zanobini Giulio Pompilio Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells Stem Cells International |
| title | Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells |
| title_full | Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells |
| title_fullStr | Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells |
| title_full_unstemmed | Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells |
| title_short | Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells |
| title_sort | young at heart pioneering approaches to model nonischaemic cardiomyopathy with induced pluripotent stem cells |
| url | http://dx.doi.org/10.1155/2016/4287158 |
| work_keys_str_mv | AT aoifegowran youngatheartpioneeringapproachestomodelnonischaemiccardiomyopathywithinducedpluripotentstemcells AT marcorasponi youngatheartpioneeringapproachestomodelnonischaemiccardiomyopathywithinducedpluripotentstemcells AT robertavisone youngatheartpioneeringapproachestomodelnonischaemiccardiomyopathywithinducedpluripotentstemcells AT patrizianigro youngatheartpioneeringapproachestomodelnonischaemiccardiomyopathywithinducedpluripotentstemcells AT gianlucalperrucci youngatheartpioneeringapproachestomodelnonischaemiccardiomyopathywithinducedpluripotentstemcells AT stefanorighetti youngatheartpioneeringapproachestomodelnonischaemiccardiomyopathywithinducedpluripotentstemcells AT marcozanobini youngatheartpioneeringapproachestomodelnonischaemiccardiomyopathywithinducedpluripotentstemcells AT giuliopompilio youngatheartpioneeringapproachestomodelnonischaemiccardiomyopathywithinducedpluripotentstemcells |