A Systematic Review and Meta-analysis of Single-group Studies Assessing the Role of Calcium Hydroxylapatite in Aesthetic Enhancements and Satisfaction
Background:. Many studies assess aesthetic effectiveness of calcium hydroxylapatite (CaHA), with single-group designs as the most frequently applied designs in practice. This study systematically reviewed CaHA’s effectiveness for aesthetic purposes among these studies. Methods:. A comprehensive sear...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2024-12-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006400 |
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| _version_ | 1832589741085687808 |
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| author | Mojgan Amiri, MSc Renald Meçani, MD Christa D. Niehot, MSc Terri L. Phillips, MD Katherine Goldie, MD Janina Kolb, MD Taulant Muka, PhD Hua Daughtry, PhD |
| author_facet | Mojgan Amiri, MSc Renald Meçani, MD Christa D. Niehot, MSc Terri L. Phillips, MD Katherine Goldie, MD Janina Kolb, MD Taulant Muka, PhD Hua Daughtry, PhD |
| author_sort | Mojgan Amiri, MSc |
| collection | DOAJ |
| description | Background:. Many studies assess aesthetic effectiveness of calcium hydroxylapatite (CaHA), with single-group designs as the most frequently applied designs in practice. This study systematically reviewed CaHA’s effectiveness for aesthetic purposes among these studies.
Methods:. A comprehensive search was conducted across 5 bibliographic databases. Single-group studies with at least 10 human adults were included. Summary measures of patients satisfaction and global aesthetic improvement scores were combined using the generalized linear mixed model. This systematic review adhered to the PRISMA reporting standards.
Results:. Of 3131 records, 46 single-group studies, majority focused on facial areas (n = 32), were included for final qualitative analysis. A total number of 27 studies were included in the meta-analysis. Findings of the meta-analysis showed that 98% (95% confidence interval [CI], 91%–99%; I2, 0.0%) of patients were satisfied with the injection results in the facial area and 90% (95% CI, 67%–97%, I2, 35%) in other treated body areas. Also, patients reported 89% (95% CI, 76%–96%; I2, 65%) improvement on the global aesthetic improvement scale in facial areas and 94% (95% CI, 75%–99%; I2, 0.0%) in other treated regions. Similarly, investigators reported global aesthetic improvement in 92% of patients (95% CI, 33%–100%; I2, 92%) in facial areas and 95% (95% CI, 1%–100%; I2, 89%) in other treated areas.
Conclusions:. Our findings showed aesthetic improvements and satisfaction following CaHA injections in both facial and nonfacial areas. However, studies focusing on nonfacial regions are limited. We recommend more rigorously designed trials to better understand CaHA’s clinical effects. |
| format | Article |
| id | doaj-art-f74d48fee5d14b76880c690de5da669b |
| institution | Kabale University |
| issn | 2169-7574 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj-art-f74d48fee5d14b76880c690de5da669b2025-01-24T09:19:45ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742024-12-011212e640010.1097/GOX.0000000000006400202412000-00066A Systematic Review and Meta-analysis of Single-group Studies Assessing the Role of Calcium Hydroxylapatite in Aesthetic Enhancements and SatisfactionMojgan Amiri, MSc0Renald Meçani, MD1Christa D. Niehot, MSc2Terri L. Phillips, MD3Katherine Goldie, MD4Janina Kolb, MD5Taulant Muka, PhD6Hua Daughtry, PhD7From the * Epistudia, Bern, SwitzerlandFrom the * Epistudia, Bern, Switzerland‡ Literature Searches Support, Dordrecht, The Netherlands§ Merz North America, Inc. Raleigh, NC¶ Clinic 77, London, United Kingdom∥ Merz Aesthetics GmbH, Frankfurt am Main, Germany.From the * Epistudia, Bern, Switzerland§ Merz North America, Inc. Raleigh, NCBackground:. Many studies assess aesthetic effectiveness of calcium hydroxylapatite (CaHA), with single-group designs as the most frequently applied designs in practice. This study systematically reviewed CaHA’s effectiveness for aesthetic purposes among these studies. Methods:. A comprehensive search was conducted across 5 bibliographic databases. Single-group studies with at least 10 human adults were included. Summary measures of patients satisfaction and global aesthetic improvement scores were combined using the generalized linear mixed model. This systematic review adhered to the PRISMA reporting standards. Results:. Of 3131 records, 46 single-group studies, majority focused on facial areas (n = 32), were included for final qualitative analysis. A total number of 27 studies were included in the meta-analysis. Findings of the meta-analysis showed that 98% (95% confidence interval [CI], 91%–99%; I2, 0.0%) of patients were satisfied with the injection results in the facial area and 90% (95% CI, 67%–97%, I2, 35%) in other treated body areas. Also, patients reported 89% (95% CI, 76%–96%; I2, 65%) improvement on the global aesthetic improvement scale in facial areas and 94% (95% CI, 75%–99%; I2, 0.0%) in other treated regions. Similarly, investigators reported global aesthetic improvement in 92% of patients (95% CI, 33%–100%; I2, 92%) in facial areas and 95% (95% CI, 1%–100%; I2, 89%) in other treated areas. Conclusions:. Our findings showed aesthetic improvements and satisfaction following CaHA injections in both facial and nonfacial areas. However, studies focusing on nonfacial regions are limited. We recommend more rigorously designed trials to better understand CaHA’s clinical effects.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006400 |
| spellingShingle | Mojgan Amiri, MSc Renald Meçani, MD Christa D. Niehot, MSc Terri L. Phillips, MD Katherine Goldie, MD Janina Kolb, MD Taulant Muka, PhD Hua Daughtry, PhD A Systematic Review and Meta-analysis of Single-group Studies Assessing the Role of Calcium Hydroxylapatite in Aesthetic Enhancements and Satisfaction Plastic and Reconstructive Surgery, Global Open |
| title | A Systematic Review and Meta-analysis of Single-group Studies Assessing the Role of Calcium Hydroxylapatite in Aesthetic Enhancements and Satisfaction |
| title_full | A Systematic Review and Meta-analysis of Single-group Studies Assessing the Role of Calcium Hydroxylapatite in Aesthetic Enhancements and Satisfaction |
| title_fullStr | A Systematic Review and Meta-analysis of Single-group Studies Assessing the Role of Calcium Hydroxylapatite in Aesthetic Enhancements and Satisfaction |
| title_full_unstemmed | A Systematic Review and Meta-analysis of Single-group Studies Assessing the Role of Calcium Hydroxylapatite in Aesthetic Enhancements and Satisfaction |
| title_short | A Systematic Review and Meta-analysis of Single-group Studies Assessing the Role of Calcium Hydroxylapatite in Aesthetic Enhancements and Satisfaction |
| title_sort | systematic review and meta analysis of single group studies assessing the role of calcium hydroxylapatite in aesthetic enhancements and satisfaction |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006400 |
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