Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent Individuals
In cocaine-dependent individuals, sleep is disturbed during cocaine use and abstinence, highlighting the importance of examining the behavioral and homeostatic response to acute sleep loss in these individuals. The current study was designed to identify a differential effect of sleep deprivation on...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/947879 |
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| author | George H. Trksak Bethany K. Bracken J. Eric Jensen David T. Plante David M. Penetar Wendy L. Tartarini Melissa A. Maywalt Cynthia M. Dorsey Perry F. Renshaw Scott E. Lukas |
| author_facet | George H. Trksak Bethany K. Bracken J. Eric Jensen David T. Plante David M. Penetar Wendy L. Tartarini Melissa A. Maywalt Cynthia M. Dorsey Perry F. Renshaw Scott E. Lukas |
| author_sort | George H. Trksak |
| collection | DOAJ |
| description | In cocaine-dependent individuals, sleep is disturbed during cocaine use and abstinence, highlighting the importance of examining the behavioral and homeostatic response to acute sleep loss in these individuals. The current study was designed to identify a differential effect of sleep deprivation on brain bioenergetics, cognitive performance, and sleep between cocaine-dependent and healthy control participants. 14 healthy control and 8 cocaine-dependent participants experienced consecutive nights of baseline, total sleep deprivation, and recovery sleep in the research laboratory. Participants underwent [31]P magnetic resonance spectroscopy (MRS) brain imaging, polysomnography, Continuous Performance Task, and Digit Symbol Substitution Task. Following recovery sleep, [31]P MRS scans revealed that cocaine-dependent participants exhibited elevated global brain β-NTP (direct measure of adenosine triphosphate), α-NTP, and total NTP levels compared to those of healthy controls. Cocaine-dependent participants performed worse on the Continuous Performance Task and Digit Symbol Substitution Task at baseline compared to healthy control participants, but sleep deprivation did not worsen cognitive performance in either group. Enhancements of brain ATP levels in cocaine dependent participants following recovery sleep may reflect a greater impact of sleep deprivation on sleep homeostasis, which may highlight the importance of monitoring sleep during abstinence and the potential influence of sleep loss in drug relapse. |
| format | Article |
| id | doaj-art-f73ce908234147099797ac3e1e67a60b |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-f73ce908234147099797ac3e1e67a60b2025-02-03T01:12:56ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/947879947879Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent IndividualsGeorge H. Trksak0Bethany K. Bracken1J. Eric Jensen2David T. Plante3David M. Penetar4Wendy L. Tartarini5Melissa A. Maywalt6Cynthia M. Dorsey7Perry F. Renshaw8Scott E. Lukas9Behavioral Psychopharmacology Research Lab, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USABehavioral Psychopharmacology Research Lab, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USAMcLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USAHarvard Medical School, 25 Shattuck Street, Boston, MA 02115, USABehavioral Psychopharmacology Research Lab, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USABehavioral Psychopharmacology Research Lab, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USASleep Research Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USAMcLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USAMcLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USABehavioral Psychopharmacology Research Lab, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USAIn cocaine-dependent individuals, sleep is disturbed during cocaine use and abstinence, highlighting the importance of examining the behavioral and homeostatic response to acute sleep loss in these individuals. The current study was designed to identify a differential effect of sleep deprivation on brain bioenergetics, cognitive performance, and sleep between cocaine-dependent and healthy control participants. 14 healthy control and 8 cocaine-dependent participants experienced consecutive nights of baseline, total sleep deprivation, and recovery sleep in the research laboratory. Participants underwent [31]P magnetic resonance spectroscopy (MRS) brain imaging, polysomnography, Continuous Performance Task, and Digit Symbol Substitution Task. Following recovery sleep, [31]P MRS scans revealed that cocaine-dependent participants exhibited elevated global brain β-NTP (direct measure of adenosine triphosphate), α-NTP, and total NTP levels compared to those of healthy controls. Cocaine-dependent participants performed worse on the Continuous Performance Task and Digit Symbol Substitution Task at baseline compared to healthy control participants, but sleep deprivation did not worsen cognitive performance in either group. Enhancements of brain ATP levels in cocaine dependent participants following recovery sleep may reflect a greater impact of sleep deprivation on sleep homeostasis, which may highlight the importance of monitoring sleep during abstinence and the potential influence of sleep loss in drug relapse.http://dx.doi.org/10.1155/2013/947879 |
| spellingShingle | George H. Trksak Bethany K. Bracken J. Eric Jensen David T. Plante David M. Penetar Wendy L. Tartarini Melissa A. Maywalt Cynthia M. Dorsey Perry F. Renshaw Scott E. Lukas Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent Individuals The Scientific World Journal |
| title | Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent Individuals |
| title_full | Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent Individuals |
| title_fullStr | Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent Individuals |
| title_full_unstemmed | Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent Individuals |
| title_short | Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent Individuals |
| title_sort | effects of sleep deprivation on brain bioenergetics sleep and cognitive performance in cocaine dependent individuals |
| url | http://dx.doi.org/10.1155/2013/947879 |
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