LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

Abstract Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities that could be harnessed for therapeutic benefit. Using CRISPR‐activation screens in ferroptosis hypersensitive cells, we identify th...

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Main Authors: Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira dos Santos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silva, Adriana Przybylla, Petra Zeisberger, Giulio Superti‐Furga, Martin Eilers, Marcus Conrad, Marietta Fabiano, Ulrich Schweizer, Matthias Fischer, Almut Schulze, Andreas Trumpp, José Pedro Friedmann Angeli
Format: Article
Language:English
Published: Springer Nature 2023-07-01
Series:EMBO Molecular Medicine
Subjects:
ferroptosis
neuroblastoma
selenocysteine
selenoprotein
synthetic lethality
Online Access:https://doi.org/10.15252/emmm.202318014
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