Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases
As the population ages, musculoskeletal diseases (MSK) have emerged as a significant burden for individuals, healthcare systems, and social care systems. Recently, regenerative medicine has exhibited vast potential in age-related MSK, with mesenchymal stromal cells (MSCs) and their derived exosomes...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S104366182500043X |
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| author | Lixin Liu Siwen Chen Yantao Song Longwei Cui Yiman Chen Jiangli Xia Yibo Fan Liqun Yang Lina Yang |
| author_facet | Lixin Liu Siwen Chen Yantao Song Longwei Cui Yiman Chen Jiangli Xia Yibo Fan Liqun Yang Lina Yang |
| author_sort | Lixin Liu |
| collection | DOAJ |
| description | As the population ages, musculoskeletal diseases (MSK) have emerged as a significant burden for individuals, healthcare systems, and social care systems. Recently, regenerative medicine has exhibited vast potential in age-related MSK, with mesenchymal stromal cells (MSCs) and their derived exosomes (Exos) therapies showing distinct advantages. However, these therapies face several limitations, including issues related to ensuring stability and effective distribution within the body. Hydrogels, acting as an ideal carrier, can enhance the therapeutic effects and application range of MSCs and Exos derived from MSCs (MSC-Exos). Therefore, this review comprehensively summarizes the application progress of MSCs and MSC-Exos combined with hydrogels in age-related MSK disease research. It aims to provide a detailed perspective, showcasing the functional enhancement of MSCs and MSC-Exos when incorporated into hydrogels. Additionally, this review explores their potential and challenges in treating age-related MSK diseases, offering references for future research directions and potential innovative strategies. |
| format | Article |
| id | doaj-art-f72af3357b1940ffba3e2f5ef1271ffb |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-f72af3357b1940ffba3e2f5ef1271ffb2025-02-06T05:11:05ZengElsevierPharmacological Research1096-11862025-03-01213107618Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseasesLixin Liu0Siwen Chen1Yantao Song2Longwei Cui3Yiman Chen4Jiangli Xia5Yibo Fan6Liqun Yang7Lina Yang8Departments of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR ChinaResearch Center for Biomedical Materials, Shenyang Key Laboratory of Biomedical Polymers, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang 110004, PR China; Center for Molecular Science and Engineering, College of Science, Northeastern University, Shenyang 110819, PR ChinaDepartment of Plastic Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110002, PR ChinaDepartment of Plastic Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110002, PR ChinaDepartments of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR ChinaSchool of Pharmaceutical Science, Liaoning University, Shenyang 110036, PR ChinaDepartment of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAResearch Center for Biomedical Materials, Shenyang Key Laboratory of Biomedical Polymers, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang 110004, PR China; Corresponding author.Departments of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China; Department of International Physical Examination Center, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China; Corresponding author at: Departments of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China.As the population ages, musculoskeletal diseases (MSK) have emerged as a significant burden for individuals, healthcare systems, and social care systems. Recently, regenerative medicine has exhibited vast potential in age-related MSK, with mesenchymal stromal cells (MSCs) and their derived exosomes (Exos) therapies showing distinct advantages. However, these therapies face several limitations, including issues related to ensuring stability and effective distribution within the body. Hydrogels, acting as an ideal carrier, can enhance the therapeutic effects and application range of MSCs and Exos derived from MSCs (MSC-Exos). Therefore, this review comprehensively summarizes the application progress of MSCs and MSC-Exos combined with hydrogels in age-related MSK disease research. It aims to provide a detailed perspective, showcasing the functional enhancement of MSCs and MSC-Exos when incorporated into hydrogels. Additionally, this review explores their potential and challenges in treating age-related MSK diseases, offering references for future research directions and potential innovative strategies.http://www.sciencedirect.com/science/article/pii/S104366182500043XMusculoskeletal DiseasesHydrogelsMesenchymal stem cellsExosomeAging |
| spellingShingle | Lixin Liu Siwen Chen Yantao Song Longwei Cui Yiman Chen Jiangli Xia Yibo Fan Liqun Yang Lina Yang Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases Pharmacological Research Musculoskeletal Diseases Hydrogels Mesenchymal stem cells Exosome Aging |
| title | Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases |
| title_full | Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases |
| title_fullStr | Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases |
| title_full_unstemmed | Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases |
| title_short | Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases |
| title_sort | hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age related musculoskeletal diseases |
| topic | Musculoskeletal Diseases Hydrogels Mesenchymal stem cells Exosome Aging |
| url | http://www.sciencedirect.com/science/article/pii/S104366182500043X |
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