Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents
The scientific interest in the chemical modification of chitosan to increase its solubility and application has led to its conjugation with Schiff bases, which are interesting scaffolds endowed with diverse biological properties. The resultant chitosan-based Schiff bases (CSBs) are widely studied in...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/2/207 |
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| author | Domenico Iacopetta Alessia Catalano Jessica Ceramella Annaluisa Mariconda Assunta D’Amato Paola Checconi Stefano Aquaro Pasquale Longo Maria Stefania Sinicropi |
| author_facet | Domenico Iacopetta Alessia Catalano Jessica Ceramella Annaluisa Mariconda Assunta D’Amato Paola Checconi Stefano Aquaro Pasquale Longo Maria Stefania Sinicropi |
| author_sort | Domenico Iacopetta |
| collection | DOAJ |
| description | The scientific interest in the chemical modification of chitosan to increase its solubility and application has led to its conjugation with Schiff bases, which are interesting scaffolds endowed with diverse biological properties. The resultant chitosan-based Schiff bases (CSBs) are widely studied in scientific literature due to the myriad of activities exerted, both catalytic and biological, including anticancer, anti-inflammatory, antioxidant, and especially antimicrobial ones. Antimicrobial resistance (AMR) is one of the major public health challenges of the twenty-first century because it represents a threat to the prevention and treatment of a growing number of bacterial, parasitic, viral, and fungal infections that are no longer treatable with the available drugs. Thus, in this review, we present a brief outline of the biological activities of CSBs as well as their complexes with metals, with a particular focus on the recent literature regarding the antimicrobial effect of these captivating derivatives. |
| format | Article |
| id | doaj-art-f727b51354264839b6aae0d68057a853 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-f727b51354264839b6aae0d68057a8532025-01-24T13:43:06ZengMDPI AGMolecules1420-30492025-01-0130220710.3390/molecules30020207Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial AgentsDomenico Iacopetta0Alessia Catalano1Jessica Ceramella2Annaluisa Mariconda3Assunta D’Amato4Paola Checconi5Stefano Aquaro6Pasquale Longo7Maria Stefania Sinicropi8Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, ItalyDepartment of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, Via Orabona, 4, 70126 Bari, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, ItalyDepartment of Basic and Applied Sciences, University of Basilicata, Via dell’Ateneo Lucano, 10, 85100 Potenza, ItalyDepartment of Chemistry and Biology “A. Zambelli”, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, ItalyDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, Piazzale Salvatore Tommasi, 1, Blocco 11, Coppito, 67010 L’Aquila, ItalyDepartment of Chemistry and Biology “A. Zambelli”, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, ItalyThe scientific interest in the chemical modification of chitosan to increase its solubility and application has led to its conjugation with Schiff bases, which are interesting scaffolds endowed with diverse biological properties. The resultant chitosan-based Schiff bases (CSBs) are widely studied in scientific literature due to the myriad of activities exerted, both catalytic and biological, including anticancer, anti-inflammatory, antioxidant, and especially antimicrobial ones. Antimicrobial resistance (AMR) is one of the major public health challenges of the twenty-first century because it represents a threat to the prevention and treatment of a growing number of bacterial, parasitic, viral, and fungal infections that are no longer treatable with the available drugs. Thus, in this review, we present a brief outline of the biological activities of CSBs as well as their complexes with metals, with a particular focus on the recent literature regarding the antimicrobial effect of these captivating derivatives.https://www.mdpi.com/1420-3049/30/2/207Schiff baseschitosanantimicrobialantibacterialantifungalmetal complexes |
| spellingShingle | Domenico Iacopetta Alessia Catalano Jessica Ceramella Annaluisa Mariconda Assunta D’Amato Paola Checconi Stefano Aquaro Pasquale Longo Maria Stefania Sinicropi Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents Molecules Schiff bases chitosan antimicrobial antibacterial antifungal metal complexes |
| title | Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents |
| title_full | Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents |
| title_fullStr | Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents |
| title_full_unstemmed | Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents |
| title_short | Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents |
| title_sort | chitosan based schiff bases csbs and their metal complexes promising antimicrobial agents |
| topic | Schiff bases chitosan antimicrobial antibacterial antifungal metal complexes |
| url | https://www.mdpi.com/1420-3049/30/2/207 |
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