Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus

Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus

Obesity and metabolic disorders, such as metabolic syndrome (MetS) facilitate the development of neurodegenerative diseases and cognitive decline. Persistent neuroinflammation plays an important role in this process. Pleiotrophin (PTN) is a cytokine that regulates energy metabolism and high-fat diet...

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Main Authors: Héctor Cañeque-Rufo, Teresa Fontán-Baselga, Milagros Galán-Llario, Agata Zuccaro, María Gracia Sánchez-Alonso, Esther Gramage, María del Pilar Ramos-Álvarez, Gonzalo Herradón
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Neurobiology of Disease
Subjects:
Pleiotrophin
Neuroinflammation
Metabolic syndrome
Perineuronal nets
Obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003784
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