Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience
Introduction. Hepatitis C virus (HCV) infection is an independent risk factor for renal transplantation (RTx). Immunosuppression minimization can render better quality of life to these patients. Methods. We analyzed 132 HCV-positive RTx patients (group A) transplanted under tolerance induction proto...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2011/581485 |
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| author | P. R. Shah A. V. Vanikar M. R. Gumber H. V. Patel V. B. Kute S. M. Godara H. L. Trivedi |
| author_facet | P. R. Shah A. V. Vanikar M. R. Gumber H. V. Patel V. B. Kute S. M. Godara H. L. Trivedi |
| author_sort | P. R. Shah |
| collection | DOAJ |
| description | Introduction. Hepatitis C virus (HCV) infection is an independent risk factor for renal transplantation (RTx). Immunosuppression minimization can render better quality of life to these patients. Methods. We analyzed 132 HCV-positive RTx patients (group A) transplanted under tolerance induction protocol (TIP) and compared them with 79 controls (group B) transplanted using standard triple drugs. TIP consisted of 1 donor-specific transfusion, peripheral blood stem cell infusion, portal infusion of bone marrow, and target-specific irradiation. Their immunosuppression was cyclosporin, 2 ± 1 mg/kg BW/day + prednisone, 10 mg/day. Results. TIP had no side effects. Although unequal in size, the groups were well balanced. Group A patient survival at 1, 5, and 10 years was 92.4%, 70.4%, and 63.7%, respectively, versus 75.6%, 71.7%, and 55.7% in later, and graft survival was 92.9%, 81.5%, and 79.1% versus 91.7%, 75.7%, and 67.7%, respectively. Mean serum creatinine (mg/dL) at these time periods in former was 1.38, 1.72, and 1.87, versus 1.3, 1.75, and 2.1 in later. Altered liver functions were noted in 22% patients in former versus 31% in later. Group A had lesser rejection episodes. Conclusion. RTx using TIP in HCV-positive patients is a viable option with acceptable outcome. |
| format | Article |
| id | doaj-art-f714d04e4fcc441fb9d51171dd1acb72 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-f714d04e4fcc441fb9d51171dd1acb722025-02-03T01:28:40ZengWileyJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/581485581485Renal Transplantation in Hepatitis C Positive Patients: A Single Centre ExperienceP. R. Shah0A. V. Vanikar1M. R. Gumber2H. V. Patel3V. B. Kute4S. M. Godara5H. L. Trivedi6Department of Nephrology and Transplantation Medicine, IKDRC-ITS, Ahmedabad 380016, IndiaDepartment of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, IKDRC-ITS, Ahmedabad 380016, IndiaDepartment of Nephrology and Transplantation Medicine, IKDRC-ITS, Ahmedabad 380016, IndiaDepartment of Nephrology and Transplantation Medicine, IKDRC-ITS, Ahmedabad 380016, IndiaDepartment of Nephrology and Transplantation Medicine, IKDRC-ITS, Ahmedabad 380016, IndiaDepartment of Nephrology and Transplantation Medicine, IKDRC-ITS, Ahmedabad 380016, IndiaDepartment of Nephrology and Transplantation Medicine, IKDRC-ITS, Ahmedabad 380016, IndiaIntroduction. Hepatitis C virus (HCV) infection is an independent risk factor for renal transplantation (RTx). Immunosuppression minimization can render better quality of life to these patients. Methods. We analyzed 132 HCV-positive RTx patients (group A) transplanted under tolerance induction protocol (TIP) and compared them with 79 controls (group B) transplanted using standard triple drugs. TIP consisted of 1 donor-specific transfusion, peripheral blood stem cell infusion, portal infusion of bone marrow, and target-specific irradiation. Their immunosuppression was cyclosporin, 2 ± 1 mg/kg BW/day + prednisone, 10 mg/day. Results. TIP had no side effects. Although unequal in size, the groups were well balanced. Group A patient survival at 1, 5, and 10 years was 92.4%, 70.4%, and 63.7%, respectively, versus 75.6%, 71.7%, and 55.7% in later, and graft survival was 92.9%, 81.5%, and 79.1% versus 91.7%, 75.7%, and 67.7%, respectively. Mean serum creatinine (mg/dL) at these time periods in former was 1.38, 1.72, and 1.87, versus 1.3, 1.75, and 2.1 in later. Altered liver functions were noted in 22% patients in former versus 31% in later. Group A had lesser rejection episodes. Conclusion. RTx using TIP in HCV-positive patients is a viable option with acceptable outcome.http://dx.doi.org/10.1155/2011/581485 |
| spellingShingle | P. R. Shah A. V. Vanikar M. R. Gumber H. V. Patel V. B. Kute S. M. Godara H. L. Trivedi Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience Journal of Transplantation |
| title | Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience |
| title_full | Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience |
| title_fullStr | Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience |
| title_full_unstemmed | Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience |
| title_short | Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience |
| title_sort | renal transplantation in hepatitis c positive patients a single centre experience |
| url | http://dx.doi.org/10.1155/2011/581485 |
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