Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature
Sertoli-Leydig cell tumours of the ovary (SLCT) are rare tumours predominantly caused by mutations in the DICER1 gene. We present a patient with a unilateral SLCT who had an underlying germline DICER1 gene mutation. We discuss the underlying pathology, risks, and screening opportunities available to...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2018/7927362 |
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| _version_ | 1832563192835866624 |
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| author | B. Wormald S. Elorbany H. Hanson J. W. Williams S. Heenan D. P. J. Barton |
| author_facet | B. Wormald S. Elorbany H. Hanson J. W. Williams S. Heenan D. P. J. Barton |
| author_sort | B. Wormald |
| collection | DOAJ |
| description | Sertoli-Leydig cell tumours of the ovary (SLCT) are rare tumours predominantly caused by mutations in the DICER1 gene. We present a patient with a unilateral SLCT who had an underlying germline DICER1 gene mutation. We discuss the underlying pathology, risks, and screening opportunities available to those with a mutation in this gene as SLCT is only one of a multitude of other tumours encompassing DICER1 syndrome. The condition is inherited in an autosomal dominant fashion. As such, genetic counselling is a key component of the management of women with SLCT. |
| format | Article |
| id | doaj-art-f710535dd04e4c66994ac1aae733f5c1 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-f710535dd04e4c66994ac1aae733f5c12025-02-03T01:20:55ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922018-01-01201810.1155/2018/79273627927362Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the LiteratureB. Wormald0S. Elorbany1H. Hanson2J. W. Williams3S. Heenan4D. P. J. Barton5St George’s Hospital, UKSt George’s Hospital, UKSt George’s Hospital, UKSt George’s Hospital, UKSt George’s Hospital, UKSt George’s Hospital and the Royal Marsden Hospital, UKSertoli-Leydig cell tumours of the ovary (SLCT) are rare tumours predominantly caused by mutations in the DICER1 gene. We present a patient with a unilateral SLCT who had an underlying germline DICER1 gene mutation. We discuss the underlying pathology, risks, and screening opportunities available to those with a mutation in this gene as SLCT is only one of a multitude of other tumours encompassing DICER1 syndrome. The condition is inherited in an autosomal dominant fashion. As such, genetic counselling is a key component of the management of women with SLCT.http://dx.doi.org/10.1155/2018/7927362 |
| spellingShingle | B. Wormald S. Elorbany H. Hanson J. W. Williams S. Heenan D. P. J. Barton Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature Case Reports in Obstetrics and Gynecology |
| title | Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature |
| title_full | Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature |
| title_fullStr | Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature |
| title_full_unstemmed | Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature |
| title_short | Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature |
| title_sort | sertoli leydig cell tumour and dicer1 mutation a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2018/7927362 |
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