Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy
Background. The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. Clinical and laboratory data were examined. The potential association between sera IL-33 and sST2 and the clin...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6540937 |
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| _version_ | 1832553511315832832 |
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| author | Zhihui Zhang Haifeng Wang Li Zhang Rebecca Crew Nan Zhang Xiaolei Liu Yanfang Jiang |
| author_facet | Zhihui Zhang Haifeng Wang Li Zhang Rebecca Crew Nan Zhang Xiaolei Liu Yanfang Jiang |
| author_sort | Zhihui Zhang |
| collection | DOAJ |
| description | Background. The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. Clinical and laboratory data were examined. The potential association between sera IL-33 and sST2 and the clinical parameters in IgAN patients were analyzed. Results. No difference was discovered in IL-33 concentrations between IgAN patients and HCs; however, the sST2 were significantly higher in each stage of IgAN progression than in the HC. The concentration of sST2 was positively correlated with IL-33 levels in IgAN patients. Higher levels of sera IL-2, IL-4, IL-10, IL-17A, and IFN-γ were detected in patients compared to the HC. The concentration of serum sST2 was positively correlated with the levels of IL-10 in IgAN patients. Furthermore, serum sST2 was negatively correlated with the values of eGFR and serum calcium. Serum sST2 was positively correlated with 24-hour urinary protein, serum phosphorus, and serum IgA; however, serum IL-33 was not associated with these. Following treatment, serum sST2 was significantly decreased, while sera IL-4 and IL-10 were significantly increased. Conclusions. Increased sST2 and IL-10 but not IL-33 may be involved in the pathogenic process of IgAN. |
| format | Article |
| id | doaj-art-f70f5603aaa3463ab2b4f27094dad4bf |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f70f5603aaa3463ab2b4f27094dad4bf2025-02-03T05:53:57ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/65409376540937Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA NephropathyZhihui Zhang0Haifeng Wang1Li Zhang2Rebecca Crew3Nan Zhang4Xiaolei Liu5Yanfang Jiang6Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, ChinaGenetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Nephrology, The First Hospital of Jilin University, Changchun 130021, ChinaUniversity of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAGenetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, ChinaKey Laboratory of Zoonoses Research, Ministry of Education, The First Hospital of Jilin University, Changchun 130021, ChinaGenetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, ChinaBackground. The IL-33/ST2 axis is involved in humoral immune responses. Method. The concentrations of sera IL-33 and sST2 in 74 patients and 34 healthy controls (HC) were measured by ELISA. Clinical and laboratory data were examined. The potential association between sera IL-33 and sST2 and the clinical parameters in IgAN patients were analyzed. Results. No difference was discovered in IL-33 concentrations between IgAN patients and HCs; however, the sST2 were significantly higher in each stage of IgAN progression than in the HC. The concentration of sST2 was positively correlated with IL-33 levels in IgAN patients. Higher levels of sera IL-2, IL-4, IL-10, IL-17A, and IFN-γ were detected in patients compared to the HC. The concentration of serum sST2 was positively correlated with the levels of IL-10 in IgAN patients. Furthermore, serum sST2 was negatively correlated with the values of eGFR and serum calcium. Serum sST2 was positively correlated with 24-hour urinary protein, serum phosphorus, and serum IgA; however, serum IL-33 was not associated with these. Following treatment, serum sST2 was significantly decreased, while sera IL-4 and IL-10 were significantly increased. Conclusions. Increased sST2 and IL-10 but not IL-33 may be involved in the pathogenic process of IgAN.http://dx.doi.org/10.1155/2016/6540937 |
| spellingShingle | Zhihui Zhang Haifeng Wang Li Zhang Rebecca Crew Nan Zhang Xiaolei Liu Yanfang Jiang Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy Journal of Immunology Research |
| title | Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy |
| title_full | Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy |
| title_fullStr | Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy |
| title_full_unstemmed | Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy |
| title_short | Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy |
| title_sort | serum levels of soluble st2 and il 10 are associated with disease severity in patients with iga nephropathy |
| url | http://dx.doi.org/10.1155/2016/6540937 |
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