Laser-Induced Thermal Therapy in the Management of Low-Grade Gliomas: A Narrative Review
Background: Low-grade gliomas (LGGs) are slow-growing, World Health Organization Grade I and II tumors that can transform into more aggres-sive malignancies over time. This transformation pre- sents significant challenges in managing the burden of health care. Laser-induced thermal therapy (LITT)...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Riyadh Second Health Cluster Research Center, King Fahad Medical City (KFMC)
2025-01-01
|
| Series: | The Journal of Medicine, Law & Public Health |
| Subjects: | |
| Online Access: | https://jmlph.net/index.php/jmlph/article/view/177 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832579210586095616 |
|---|---|
| author | Ibrahim Omar hamed Dalabeh Hossam Salameh Yasmin Dahabreh Abdallah Ali suleiman Al-Zayadneh Mehreen Amir Ayman Haitham Khaled Malak A. Hassan Azad Jehad Makableh Mohammad Omar hamed Dalabeh |
| author_facet | Ibrahim Omar hamed Dalabeh Hossam Salameh Yasmin Dahabreh Abdallah Ali suleiman Al-Zayadneh Mehreen Amir Ayman Haitham Khaled Malak A. Hassan Azad Jehad Makableh Mohammad Omar hamed Dalabeh |
| author_sort | Ibrahim Omar hamed Dalabeh |
| collection | DOAJ |
| description |
Background:
Low-grade gliomas (LGGs) are slow-growing, World Health Organization Grade I and II tumors that can transform into more aggres-sive malignancies over time. This transformation pre- sents significant challenges in managing the burden of health care. Laser-induced thermal therapy (LITT) has emerged as a promising minimally invasive treat-ment option for LGGs, offering precise tumor ablation with minimal damage to surrounding tissues.
Method:
This narrative review synthesizes data from relevant studies on the evolution, clinical manifestations, mo-lecular characteristics, and emerging management strategies for LGGs, with a focus on the role of LITT.
Results:
LITT, a minimally invasive technique, offers targeted tumor ablation with the added benefit of disrupting the blood-brain barrier to enhance drug delivery. Studies have shown that LITT can effectively reduce tumor size and improve survival rates in patients with both primary and recurrent gliomas. However, challenges such as procedure-related complications, including motor deficits and cerebral edema, as well as the need for further research on long-term efficacy, remain.
Conclusion:
LITT represents a significant advancement in the treatment of LGGs, combining precision and minimal invasiveness. Future studies should focus on optimiz-ing protocols, integrating molecular and genetic in-sights, and assessing long-term outcomes to enhance therapeutic efficacy and patient quality of life.
|
| format | Article |
| id | doaj-art-f6fb4c024c134969be62e2902e4b0823 |
| institution | Kabale University |
| issn | 2788-9815 2788-791X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Riyadh Second Health Cluster Research Center, King Fahad Medical City (KFMC) |
| record_format | Article |
| series | The Journal of Medicine, Law & Public Health |
| spelling | doaj-art-f6fb4c024c134969be62e2902e4b08232025-01-30T12:38:35ZengRiyadh Second Health Cluster Research Center, King Fahad Medical City (KFMC)The Journal of Medicine, Law & Public Health2788-98152788-791X2025-01-0152Laser-Induced Thermal Therapy in the Management of Low-Grade Gliomas: A Narrative ReviewIbrahim Omar hamed Dalabeh0Hossam Salameh1Yasmin Dahabreh2Abdallah Ali suleiman Al-Zayadneh3Mehreen Amir4Ayman Haitham Khaled5Malak A. Hassan6Azad Jehad Makableh7Mohammad Omar hamed Dalabeh8Faculty of Medicine, Yarmouk University, Irbid, JordanFaculty of medicine, An-Najah National University, Nablus, PalestineFaculty of medicine, An-Najah National University, Nablus, PalestineFaculty of Medicine, Yarmouk University, Irbid, JordanKarachi medical and dental college, Karachi university, Karachi,Pakistan.Faculty of medicine, An-Najah National University, Nablus, PalestineFaculty of Medicine, Alexandria University, Alexandria, EgyptFaculty of Medicine, Yarmouk University, Irbid, JordanENT Department, Royal Medical Services, Amman, Jordan Background: Low-grade gliomas (LGGs) are slow-growing, World Health Organization Grade I and II tumors that can transform into more aggres-sive malignancies over time. This transformation pre- sents significant challenges in managing the burden of health care. Laser-induced thermal therapy (LITT) has emerged as a promising minimally invasive treat-ment option for LGGs, offering precise tumor ablation with minimal damage to surrounding tissues. Method: This narrative review synthesizes data from relevant studies on the evolution, clinical manifestations, mo-lecular characteristics, and emerging management strategies for LGGs, with a focus on the role of LITT. Results: LITT, a minimally invasive technique, offers targeted tumor ablation with the added benefit of disrupting the blood-brain barrier to enhance drug delivery. Studies have shown that LITT can effectively reduce tumor size and improve survival rates in patients with both primary and recurrent gliomas. However, challenges such as procedure-related complications, including motor deficits and cerebral edema, as well as the need for further research on long-term efficacy, remain. Conclusion: LITT represents a significant advancement in the treatment of LGGs, combining precision and minimal invasiveness. Future studies should focus on optimiz-ing protocols, integrating molecular and genetic in-sights, and assessing long-term outcomes to enhance therapeutic efficacy and patient quality of life. https://jmlph.net/index.php/jmlph/article/view/177Blood-Brain BarrierGliomaLaser Therapy |
| spellingShingle | Ibrahim Omar hamed Dalabeh Hossam Salameh Yasmin Dahabreh Abdallah Ali suleiman Al-Zayadneh Mehreen Amir Ayman Haitham Khaled Malak A. Hassan Azad Jehad Makableh Mohammad Omar hamed Dalabeh Laser-Induced Thermal Therapy in the Management of Low-Grade Gliomas: A Narrative Review The Journal of Medicine, Law & Public Health Blood-Brain Barrier Glioma Laser Therapy |
| title | Laser-Induced Thermal Therapy in the Management of Low-Grade Gliomas: A Narrative Review |
| title_full | Laser-Induced Thermal Therapy in the Management of Low-Grade Gliomas: A Narrative Review |
| title_fullStr | Laser-Induced Thermal Therapy in the Management of Low-Grade Gliomas: A Narrative Review |
| title_full_unstemmed | Laser-Induced Thermal Therapy in the Management of Low-Grade Gliomas: A Narrative Review |
| title_short | Laser-Induced Thermal Therapy in the Management of Low-Grade Gliomas: A Narrative Review |
| title_sort | laser induced thermal therapy in the management of low grade gliomas a narrative review |
| topic | Blood-Brain Barrier Glioma Laser Therapy |
| url | https://jmlph.net/index.php/jmlph/article/view/177 |
| work_keys_str_mv | AT ibrahimomarhameddalabeh laserinducedthermaltherapyinthemanagementoflowgradegliomasanarrativereview AT hossamsalameh laserinducedthermaltherapyinthemanagementoflowgradegliomasanarrativereview AT yasmindahabreh laserinducedthermaltherapyinthemanagementoflowgradegliomasanarrativereview AT abdallahalisuleimanalzayadneh laserinducedthermaltherapyinthemanagementoflowgradegliomasanarrativereview AT mehreenamir laserinducedthermaltherapyinthemanagementoflowgradegliomasanarrativereview AT aymanhaithamkhaled laserinducedthermaltherapyinthemanagementoflowgradegliomasanarrativereview AT malakahassan laserinducedthermaltherapyinthemanagementoflowgradegliomasanarrativereview AT azadjehadmakableh laserinducedthermaltherapyinthemanagementoflowgradegliomasanarrativereview AT mohammadomarhameddalabeh laserinducedthermaltherapyinthemanagementoflowgradegliomasanarrativereview |