NF-κB-Inducing Kinase Is Essential for Effective c-Rel Transactivation and Binding to the <i>Il12b</i> Promoter in Macrophages

NF-κB-Inducing Kinase Is Essential for Effective c-Rel Transactivation and Binding to the <i>Il12b</i> Promoter in Macrophages

This study investigates the role of NIK in activating specific inflammatory genes in macrophages, focusing on the effect of a mutation in NIK found in alymphoplasia (<i>aly</i>/<i>aly</i>) mice. Mouse peritoneal macrophages from <i>aly</i>/<i>aly</i> m...

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Bibliographic Details
Main Authors: Natalia Cuesta, Anna D. Staniszewska, Cristóbal Moreno, Carmen Punzón, Manuel Fresno
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biology
Subjects:
macrophages
NIK
IL-12
c-Rel
Online Access:https://www.mdpi.com/2079-7737/14/1/33
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